Abstract:

Objective

To investigate the clinical characteristics and prognostic factors of patients undergoing left-sided retroperitoneal tumour resection combined with organ resection.

Methods

The clinical data of 55 patients who underwent left-sided retroperitoneal tumour excision combined with organ resection in the Department of Surgical Oncology of Minhang Branch of Fudan University Cancer Hospital were retrospectively analysed from December 2016 to December 2022.The clinical characteristics, surgical modalities, overall survival (OS), and recurrence-free survival (RFS) of the patients were analysed.Kaplan-Meier curves were used for survival analysis.Cox regression analysis was used to explore the factors influencing patients’ long-term prognosis after left-sided retroperitoneal tumour resection combined with organ resection.

Results

All the 55 patients achieved complete resection of the tumour.Their median age was 60 (range, 17～84 ) years.Median tumour diameter was 16 (range, 6～45) cm.Median follow-up time was 26 (range, 3～73) months.The incidence of postoperative Clavien-Dindo grade III complications was 14.5%(8/55).The 1-, 3-, and 5-year OS rates were 87.2%, 83.5%, and 70.3%, respectively, and the 1-, 3-, and 5-year RFS rates were 80.0%, 58.6%, and 44.0%, respectively.Cox univariate and multivariate analyses showed that only pathological grade and tumour diameter were factors affecting the prognosis of the patients, whereas age, gender, being operated for the first time or not, case type, number of combined organ resections, and intraoperative bleeding were were not.Only pathological grade and being operate for the first time or not were factors affecting the RFS of patients, while age, gender, tumour diameter, case type, number of combined organ resections, and amount of intraoperative bleeding were not.

Conclusion

Left-sided retroperitoneal tumour resection combined with organ resection facilitates complete resection of the retroperitoneal tumour with manageable postoperative complications.Pathological grade and tumour diameter are risk factors for patient prognosis, and postoperative pathological grade and being operate for the first time or not are risk factors for recurrence-free survival of patients.

Key words: Retroperitoneal tumor, Organ resection, Multivisceral resection, Surgical operation, Prognosis