Progress in research of age-related differences in organ protection by remote ischemic preconditioning

doi:10.3877/cma.j.issn.1674-0785.2024.12.012

Abstract

Abstract:

Remote ischemic preconditioning (RIPC) refers to the method of implementing transient ischemia-reperfusion in the distal limb to human vital organs to protect organs. Although its effectiveness and safety in the protection of vital organs have been confirmed in some clinical studies and animal experiments,its clinical effect is still controversial. The protective effect of RIPC weakens with age. Therefore, it is necessary to further study the correlation between RIPC and age as well as the underlying mechanism to better understand its potential therapeutic application prospects and provide an important basis for clinical transformation. This article reviews the age-related differences and potential therapeutic prospects of remote ischemic preconditioning based on animal experiments and clinical trials.

Key words: Remote ischemic preconditioning, Age, Ischemia-reperfusion injury

Yangchunxue Li, Jie Gao, Wenzhi Guo, Zhi Liu. Progress in research of age-related differences in organ protection by remote ischemic preconditioning[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(12): 1150-1154.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2024.12.012

https://zhlcyszz.cma-cmc.com.cn/EN/Y2024/V18/I12/1150

References 36

1	Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia:a delay of lethal cell injury in ischemic myocardium [J]. Circulation.1986 Nov;74(5):1124-1136.
2	Przyklenk K, Bauer B, Ovize M, et al. Regional ischemic'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion [J]. Circulation, 1993, 87(3): 893-899.
3	Gho BC, Schoemaker RG, Duncker DJ, et al. Myocardial protection by brief ischemia in noncardiac tissue [J]. Circulation, 1996, 94(9):2193-200.
4	Birnbaum Y, Hale SL, Kloner RA. Ischemic preconditioning at a distance: reduction of myocardial infarct size by partial reduction of blood supply combined with rapid stimulation of the gastrocnemius muscle in the rabbit [J]. Circulation. 1997 Sep 2;96(5):1641-1646.
5	Pell TJ, Baxter GF, Yellon DM, et al. Renal ischemia preconditions myocardium: role of adenosine receptors and ATP-sensitive potassium channels [J]. Am J Physiol, 1998, 275(5): H1542-H1547.
6	Siedek F, Persigehl T, Mueller RU, et al. Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using BOLD imaging at 3T [J]. MAGMA, 2018, 31(3): 367-374.
7	An JQ, Cheng YW, Guo YC, et al. Safety and efficacy of remote ischemic postconditioning after thrombolysis in patients with stroke [J].Neurology, 2020, 95(24): e3355-e3363.
8	Mieszkowski J, Stankiewicz BE, Kochanowicz A, et al. Remote ischemic preconditioning reduces marathon-induced oxidative stress and decreases liver and heart injury markers in the serum [J]. Front Physiol, 2021, 12: 731889.
9	Filaretova L, Komkova O, Sudalina M, et al. Non-invasive remote ischemic preconditioning may protect the gastric mucosa against ischemia-reperfusion-induced injury through involvement of glucocorticoids [J]. Front Pharmacol, 2021, 12: 682643.
10	Orlandi M, Masi S, Bhowruth D, et al. Remote ischemic preconditioning protects against endothelial dysfunction in a human model of systemic inflammation: a randomized clinical trial [J].Arterioscler Thromb Vasc Biol, 2021, 41(8): e417-e426.
11	Halapas A, Kapelouzou A, Chrissoheris M, et al. The effect of Remote Ischemic Preconditioning (RIPC) on myocardial injury and inflammation in patients with severe aortic valve stenosis undergoing Transcatheter Aortic Valve Replacement (TAVI) [J]. Hellenic J Cardiol,2021, 62(6): 423-428.
12	Lang JA, Kim J, Franke WD, et al. Seven consecutive days of remote ischaemic preconditioning improves cutaneous vasodilatory capacity in young adults [J]. J Physiol, 2019, 597(3): 757-765.
13	Wahlstrøm KL, Bjerrum E, Gögenur I, et al. Effect of remote ischaemic preconditioning on mortality and morbidity after noncardiac surgery: meta-analysis [J]. BJS Open, 2021, 5(2): zraa026.
14	Zheng L, Han R, Tao L, et al. Effects of remote ischemic preconditioning on prognosis in patients with lung injury: A metaanalysis [J]. J Clin Anesth, 2020, 63: 109795.
15	Lang JA, Kim J. Remote ischaemic preconditioning-translating cardiovascular benefits to humans [J]. J Physiol, 2022, 600(13): 3053-3067.
16	Bauer TM, Murphy E. Role of mitochondrial calcium and the permeability transition pore in regulating cell death [J]. Circ Res,2020, 126(2): 280-293.
17	Zhang CX, Cheng Y, Liu DZ, et al. Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats [J]. J Nanobiotechnology, 2019, 17(1): 18.
18	Pertiwi KR, Hillman RM, Scott CA, et al. Ischemia reperfusion injury produces, and ischemic preconditioning prevents, rat cardiac fibroblast differentiation: role of KATP channels [J]. J Cardiovasc Dev Dis,2019, 6(2): 22.
19	Wang Z, Wu L, Xu J, et al. Limb ischemic postconditioning alleviates postcardiac arrest syndrome through the inhibition of mitochondrial permeability transition pore opening in a porcine model [J]. Biomed Res Int, 2020, 2020: 9136097.
20	Costa AD, Garlid KD. Intramitochondrial signaling: interactions among mitoKATP, PKCepsilon, ROS, and MPT [J]. Am J Physiol Heart Circ Physiol, 2008, 295(2): H874-H882.
21	Liu X, Cao L, Zhang T, et al. Effect of remote ischemic preconditioning in patients undergoing hepatectomy with portal triad clamping: a randomized controlled trial [J]. Anesth Analg, 2019,129(6): 1742-1748.
22	Meybohm P, Bein B, Brosteanu O, et al. A multicenter trial of remote ischemic preconditioning for heart surgery [J]. N Engl J Med, 2015,373(15): 1397-1407.
23	Liang F, Liu S, Liu G, et al. Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular surgical procedures [J]. Cochrane Database Syst Rev, 2023, 1(1):CD008472.
24	Abete P, Ferrara N, Cioppa A, et al. Preconditioning does not prevent postischemic dysfunction in aging heart [J]. J Am Coll Cardiol, 1996,27(7): 1777-1786.
25	Lee TH, Yang JT, Lin JR, et al. Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent [J]. J Neurochem, 2020, 155(4): 430-447.
26	Abete P, Ferrara N, Cacciatore F, et al. Angina-induced protection against myocardial infarction in adult and elderly patients: a loss of preconditioning mechanism in the aging heart? [J]. J Am Coll Cardiol,1997, 30(4): 947-954.
27	Della-Morte D, Cacciatore F, Salsano E, et al. Age-related reduction of cerebral ischemic preconditioning: myth or reality? [J]. Clin Interv Aging, 2013, 8: 1055-1061.
28	van den Munckhof I, Riksen N, Seeger JP, et al. Aging attenuates the protective effect of ischemic preconditioning against endothelial ischemia-reperfusion injury in humans [J]. Am J Physiol Heart Circ Physiol, 2013, 304(12): H1727-H1732.
29	Lee TM, Su SF, Chou TF, et al. Loss of preconditioning by attenuated activation of myocardial ATP-sensitive potassium channels in elderly patients undergoing coronary angioplasty [J]. Circulation, 2002,105(3): 334-340.
30	Behmenburg F, Heinen A, Bruch LV, et al. Cardioprotection by remote ischemic preconditioning is blocked in the aged rat heart in vivo [J]. J Cardiothorac Vasc Anesth, 2017, 31(4): 1223-1226.
31	Heinen A, Behmenburg F, Aytulun A, et al. The release of cardioprotective humoral factors after remote ischemic preconditioning in humans is age- and sex-dependent [J]. J Transl Med, 2018, 16(1):112.
32	Ekeloef S, Gundel O, Falkenberg A, et al. The effect of remote ischaemic preconditioning on endothelial function after hip fracture surgery [J]. Acta Anaesthesiol Scand, 2021, 65(2): 169-175.
33	Zhou C, Bulluck H, Fang N, et al. Age and surgical complexity impact on renoprotection by remote ischemic preconditioning during adult cardiac surgery: a meta analysis [J]. Sci Rep, 2017, 7(1): 215.
34	Herrod PJJ, Lund JN, Phillips BE. Time-efficient physical activity interventions to reduce blood pressure in older adults: a randomised controlled trial [EJ]. Age Ageing, 2021, 50(3): 980-984.
35	高山, 董有静. 老年外科患者虚弱研究进展 [J/OL]. 中华临床医师杂志：电子版, 2023, 17(3): 343-348.
36	Wojtovich AP, Nadtochiy SM, Brookes PS, et al. Ischemic preconditioning: the role of mitochondria and aging [J]. Exp Gerontol,2012, 47(1): 1-7.

[1]	Hao Chen, Liang Lin, Laibin Zou, Shenglan Guo. Mechanisms of gallstone and liver injury induced by lithogenic diet [J]. Chinese Archives of General Surgery(Electronic Edition), 2025, 19(01): 42-47.
[2]	Zhenzhen Li, Honggang Wang, Lili Cui, Yueqin Miu, Wanlu Liu. Safety and anti-reflux effect of modified tubular gastro-esophagostomy in laparoscopic proximal gastrectomy for gastrointestinal reconstruction [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(02): 176-179.
[3]	Chongwen Deng, Xiwang Liao, Youxiong Shi, Jun Gong, Hong Zhong. Clinical study of laparoscopic D2 radical treatment of gastric cancer and paraaortic lymph node dissection in the treatment of locally advanced gastric cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(02): 180-183.
[4]	Wei Zhang, Dandan Shang, Peizhong Shang, Xiaowu Li, Jianjun Miao, Bing Liu. Acute cholecystitis over 80 years old was treated with ampulla horological localization and gallbladder abandonment in laparoscopic surgery [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(02): 188-191.
[5]	Yinan Xu. Curative effect of different operation methods in the treatment of obstructive left colorectal cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(01): 72-75.
[6]	Yue Zhang, Ke Zhang, Sisi Deng, Qing Xiang, Yahao Guo, Jian Cao, Tao Luo, Zhan'ao Meng. Application of deep learning-based image reconstruction with three low scheme in renal artery angiography [J]. Chinese Journal of Endourology(Electronic Edition), 2025, 19(01): 76-82.
[7]	Hexiang Kong, Xiangmei Shui, Yuhua Dong, Yangyang Zhu. Application of strategy optimization management mode under the intelligent health education platform in adult patients undergoing inguinal hernia surgery [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2025, 19(01): 104-108.
[8]	Yulin Huang, Zhenling Ji. Effect of different hernia patches on collagen deposition in wound healing [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2025, 19(01): 25-30.
[9]	YuHao Qiu, Jinxiang Huang, Xiaoxuan Zhu, Feng Luo, He Huang, Hui Yao, Xue Wang. Application of the multi-disciplinary team combined with enhanced recovery after surgery model in the diagnosis and treatment of hiatal hernia [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2025, 19(01): 56-62.
[10]	Junyi Wang, Zhenfeng Xue. Application of absorbable mesh in open inguinal hernia repair in elderly patients [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2025, 19(01): 88-91.
[11]	Hongqian Liu, qi Ma, Juanjuan Chen, Chengjun Wang, Lingling Wu, Xiying Feng. Expression and clinical significance of miR-150-5p in the serum of patients with Mycobacterium tuberculosis infection in qinghai province [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2025, 18(01): 42-47.
[12]	Yihang Shi, Xishan Wang. Analysis of the development history of colorectal surgery [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2025, 14(01): 29-39.
[13]	Haoyue Zhang, Huiting Zhu, Honghao Wu, Yehuang Wang, Ling Ji, Yaxian Wang, Yang Zhang. A prospective， multicentre and randomised controlled study of initiative irrigation and drainage treatment （IIDT） after high complex anal fistula operation [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2025, 14(01): 62-70.
[14]	Xiangyun Ye, Xiyang Ma, Fang He. A case of postpartum hemorrhage complicated with pulmonary hemorrhage and literature review [J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2025, 14(01): 46-53.
[15]	Ya Tan, Li Lu. Cox regression analysis of factors related to natural pregnancy after four-dimensional hysterosalpingocontrast sonography in women with infertility [J]. Chinese Journal of Diagnostics(Electronic Edition), 2025, 13(01): 26-31.

Please choose a citation manager

Content to export