Abstract:

Objective

To evaluate the efficacy and safety of cefdinil dispersible tablets combined with minimally invasive rotatectomy in the treatment of plasma cell mastitis （PCM）.

Methods

A total of 86 patients with PCM admitted to Civil Aviation General Hospital from August 2023 to May 2024 were randomly divided into a conventional treatment group （n=28， treated by incision and drainage）， a control group （n=29， treated with cefdinir dispersible tablets combined with incision and drainage）， and a combination treatment group （n=29， treated with cefdinir dispersible tablets combined with minimally invasive rotatectomy）. Operation related indexes， levels of inflammatory factors， immunoglobulins （Igs），and complications were compared among the three groups.

Results

The operation related indexes in the combination treatment group were lower than those of the conventional treatment group and control group（P＜0.05）. After intervention， the levels of interleukin-6 （IL-6）， interleukin-1α （IL-1α）， and tumor necrosis factor-α （TNF-α）， as well as the levels of IgG， IgM， and IgA， in the combination treatment group were lower than those of the conventional treatment group and control group （P＜0.05）， The total incidence of complications in the combination group was 3.45% （1/29）， which was lower than that of the conventional treatment group （13.95% （8/28） and control group （20.69%）， and there was a statistical difference among the three groups （P＜0.05）.

Conclusion

Cefdinil dispersible tablets combined with minimally invasive rotatectomy in the treatment of PCM have significant therapeutic effects and high safety， which can shorten the operation time， reduce the intraoperative blood loss， decrease the incision healing time and incision length，improve the levels of inflammatory factors and Igs， and reduce the incidence of complications.

Key words: Cefdinil dispersible tablets, Minimally invasive rotatectomy, Plasma cell mastitis, Curative effect, Safety