Abstract:

Objective

To explore the significance of serum pepsinogen in the detection of Helicobacter pylori （Hp）-associated gastritis in children.

Methods

Children with gastrointestinal symptoms were selected from August 2019 to October 2023. All children underwent gastroscopy， gastric mucosal tissue biopsy， ¹³C breath test， and serum pepsinogen determination. According to the examination results， they were divided into either an Hp infection group or a healthy control group to analyze the value of serum PG for detecting Hp-associated gastritis.

Results

Compared with the healthy control group， serum PG-I and PGII levels in Hp-related gastritis patients were significantly increased， and PG-I / PG-II ratio was significantly decreased （P＜0.05）. Multivariate Logistic regression analysis showed that only serum PG-II level was an independent risk factor for Hp-related gastritis in children. The best diagnostic critical value was 11.25 μg/L for PG-II when the Youden index was the largest.

Conclusion

Serum PG-II is helpful for the diagnosis of Hp-associated gastritis in children. When serum PG-II is＞11.25 μg/L， gastroscopy and other related examinations should be advised.

Key words: Determination of gastric function, Gastric proteinogen, Children, Helicobacter pylori, Gastritis, Serological biopsy