Progress in research of S100B protein in cardiovascular diseases

doi:10.3877/cma.j.issn.1674-0785.2025.03.010

Abstract

Abstract:

S100B is a calcium binding protein，mainly secreted by astrocytes，Schwann cells，and oligodendrocytes in the nervous system.It is commonly used clinically to evaluate brain injury and its severity.As a damage-associated molecular pattern protein，S100B can also be secreted in cardiomyocytes，causing damage to the endothelium of cardiac blood vessels，inducing apoptosis of cardiomyocytes，disrupting calcium ion homeostasis in cardiomyocytes，inhibiting the intrinsic nervous system of the heart，leading to myocardial injury and ventricular remodeling，and inducing cardiovascular events.This article reviews the progress in the research of S100B protein in cardiovascular diseases，opening up the perspective that S100B protein may be considered as a diagnostic and therapeutic target for cardiovascular diseases.

Key words: Biomarker, Inflammation, Apoptosis, S100B, Cardiovascular disease

Meiqin Wang, Haitao Pan, Xiangfei Chen, Wan Wu, Yuhe Zhou, Yanqing Wang. Progress in research of S100B protein in cardiovascular diseases[J]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(03): 229-233.

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References 64

1	Barger SW，Van Eldik LJ，Mattson MP.S100 beta protects hippocampal neurons from damage induced by glucose deprivation ［J］.Brain Res，1995，677（1）： 167-170.
2	Donato R，Sorci G，Riuzzi F，et al.S100B's double life： intracellular regulator and extracellular signal ［J］.Biochim Biophys Acta，2009，1793（6）： 1008-1022.
3	云永利，陈萍.S100B 的研究进展［J］.医学综述，2017，23（1）：46-49.
4	Michetti F，D'Ambrosi N，Toesca A，et al.The S100B story： from biomarker to active factor in neural injury ［J］.J Neurochem，2019，148（2）： 168-187.
5	Roy Choudhury S，Heflin B，Taylor E，et al.S100bCRISPR/dCas9-KRAB-mediated suppression of restores p53-mediated apoptosis in melanoma cells ［J］.Cells，2023，24，12（5）： 730.
6	Niven J，Hoare J，McGowan D，et al.S100B up-regulates macrophage production of IL1β and CCL22 and influences severity of retinal inflammation ［J］.PLoS One，2015，10（7）： e0132688.
7	陈跃武，陈家显，陈磊，等.S100B 在心血管疾病中的作用［J］.海南医学院学报，2019，25（7）： 4.
8	Tsoporis JN，Izhar S，Leong-Poi H，et al.S100B interaction with the receptor for advanced glycation end products （RAGE）： a novel receptor-mediated mechanism for myocyte apoptosis postinfarction ［J］.Circ Res，2010，106（1）： 93-101.
9	Wartchow KM，Tramontina AC，de Souza DF，et al.Insulin stimulates S100B secretion and these proteins antagonistically modulate brain glucose metabolism ［J］.Neurochem Res，2016，41（6）： 1420-1429.
10	Bellaver B，Souza DG，Souza DO，et al.Hippocampal astrocyte cultures from adult and aged rats reproduce changes in glial functionality observed in the aging brain ［J］.Mol Neurobiol，2017，54（4）： 2969-2985.
11	Cheng M，Su X，Liu D，et al.Role of neutrophil-derived S100B in acute myocardial infarction patients from the Han Chinese population［J］.Front Cardiovasc Med，2021，7： 595446.
12	Tsoporis JN，Mohammadzadeh F，Parker TG.S100B： a multifunctional role in cardiovascular pathophysiology ［J］.Amino Acids，2011，41（4）：843-847.
13	Chen Y，Zhang J，Li Y，et al.Bifunctional MoO3-x/CuS heterojunction nanozyme-driven “Turn-On” SERS signal for the sensitive detection of cerebral infarction biomarker S100B ［J］.Anal Chem，2024，96（44）：17711-17719.
14	Tiantian W，Yonghui W，Junbo L.Antibody-labeled gold nanoparticle based resonance Rayleigh scattering detection of S100B ［J］.Anal Methods，2024，16（19）： 3074-3080.
15	Romano Spica V，Volpini V，Valeriani F，et al.In silico predicting the presence of the S100B motif in edible plants and detecting its immunoreactive materials： perspectives for functional foods，dietary supplements and phytotherapies ［J］.Int J Mol Sci，2024，25（18）： 9813.
16	Liu Z，Wang J，Guo F，et al.Role of S100β in unstable angina pectoris：insights from quantitative flow ratio ［J］.Arch Med Res，2024，55（5）：103034.
17	Sakaguchi T，Yan SF，Yan SD，et al.Central role of RAGE-dependent neointimal expansion in arterial restenosis ［J］.J Clin Invest，2003，111（7）： 959-972.
18	Hwang YC，Kaneko M，Bakr S，et al.Central role for aldose reductase pathway in myocardial ischemic injury ［J］.FASEB J，2004，18（11）：1192-1199.
19	Tsoporis JN，Izhar S，Leong-Poi H，et al.S100β interaction with the Receptor for Advanced Glycation End products （RAGE） a novel receptor-mediated mechanism for myocyte apoptosis postinfarction ［J］.Circ Res，2010，106（1）： 93-101.
20	Calderon LM，Guyette FX，Doshi AA，et al.Combining NSE and S100B with clinical examination findings to predict survival after resuscitation from cardiac arrest ［J］.Resuscitation，2014，85（8）： 1025-1029.
21	Tsoporis JN，Triantafyllis AS，Kalogeropoulos AS，et al.Differential expression of circulating damage-associated molecular patterns in patients with coronary artery ectasia ［J］.Biomolecules，2023，14（1）： 10.
22	Tsirebolos G，Tsoporis JN，Drosatos IA，et al.Emerging markers of inflammation and oxidative stress as potential predictors of coronary artery disease ［J］.Int J Cardiol，2023，376： 127-133.
23	Cao T，Zhang L，Yao LL，et al.S100B promotes injury-induced vascular remodeling through modulating smooth muscle phenotype ［J］.Biochim Biophys Acta Mol Basis Dis，2017，1863（11）： 2772-2782.
24	盛乐智，程英平，王树云，等.血清S100B 蛋白、S100A6 蛋白、S100P 蛋白及C 反应蛋白水平对急性冠脉综合征患者短期预后的预测价值研究［J］.实用心脑肺血管病杂志，2018，26（4）： 15-18.
25	苏旭，张效林，程茗慧，等.S100B 在ST 段抬高型心肌梗死患者中的临床意义［J］.解放军医学杂志，2018，43（9）： 789-794.
26	Tsoporis JN，Marks A，Kahn HJ，et al.Inhibition of norepinephrineinduced cardiac hypertrophy in s100beta transgenic mice ［J］.J Clin Invest，102（8）： 1609-1616.
27	Rochette L，Malka G，Cottin Y.The Yin and Yang of alarmin S100B in the protection of myocardium ［J］.Arch Cardiovasc Dis，2021，114（6-7）： 439-442.
28	Tsoporis JN，Izhar S，Leong-Poi H，et al.S100B interaction with the receptor for advanced glycation end products （RAGE）： a novel receptor-mediated mechanism for myocyte apoptosis postinfarction ［J］.Circ Res，2010，106（1）： 93-101.
29	Tsoporis JN，Marks A，Haddad A，et al.S100B expression modulates left ventricular remodeling after myocardial infarction in mice ［J］.Circulation，2005，111（5）： 598-606.
30	Iuvone T，Esposito G，Filippis DD，et al.Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro ［J］.J Mol Med （Berl），2007，85（12）： 1379-1392.
31	Kleissner M，Sramko M，Kohoutek J，et al.Serum S100 protein is a reliable predictor of brain injury after out-of-hospital cardiac arrest： A cohort study ［J］.Front Cardiovasc Med，2021，8： 624825.
32	Calderon LM，Guyette FX，Doshi AA，et al.Combining NSE and S100B with clinical examination findings to predict survival after resuscitation from cardiac arrest ［J］.Resuscitation，2014，85（8）： 1025-1029.
33	Yang P，Zhu L，Wang S，et al.Engineered model of heart tissue repair for exploring fibrotic processes and therapeutic interventions ［J］.Nat Commun，2024，15（1）： 7996.
34	Tunay Şentürk，Sinan Çavun，Berrin Avcı，et al.Effective inhibition of cardiomyocyte apoptosis through the combination of trimetazidine and N-acetylcysteine in a rat model of myocardial ischemia and reperfusion injury ［J］.Atherosclerosis，2014，237（2）： 760-766.
35	Tsoporis JN，Marks A，Haddad A，et al.S100B expression modulates left ventricular remodeling after myocardial infarction in mice ［J］.Circulation，2005，111（5）： 598-606.
36	Tsoporis JN，Marks A，Van Eldik LJ，et al.Regulation of the S100B gene by alpha 1-adrenergic stimulation in cardiac myocytes ［J］.Am J Physiol Heart Circ Physiol，2003，284（1）： H193-203.
37	Chen Y，Chen X，Yao M，et al.Association of S100B 3'UTR polymorphism with risk of chronic heart failure in a Chinese Han population ［J］.Medicine （Baltimore），2020，99（26）： e21018.
38	Sakatani S，Seto-Ohshima A，Shinohara Y，et al.Neural-activitydependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo ［J］.J Neurosci，2008，28（43）： 10928-10936.
39	葛均波，徐勇健，王辰，等.内科学（第9 版）［M］.北京：人民卫生出版社，2018，163.
40	Traub J，Schuhmann MK，Sell R，et al.S100B serum levels in chronic heart failure patients： a multifaceted biomarker linking cardiac and cognitive dysfunction ［J］.Int J Mol Sci，2024，25（16）： 9094.
41	Hansen JH，Kissner L，Logoteta J，et al.S100B and its relation to cerebral oxygenation in neonates and infants undergoing surgery for congenital heart disease ［J］.Congenit Heart Dis，2019，14（3）：427-437.
42	Imbalzano E，Mandraffino G，Casciaro M，et al.Pathophysiological mechanism and therapeutic role of S100 proteins in cardiac failure： a systematic review ［J］.Heart Fail Rev，2016，21（5）： 463-473.
43	Li JP，Lu L，Wang LJ，et al.Increased serum levels of S100B are related to the severity of cardiac dysfunction，renal insufficiency and major cardiac events in patients with chronic heart failure ［J］.Clin Biochem，2011，44（12）： 984-988.
44	Mazzini GS，Schaf DV，Vinadé ER，et al.Increased S100B serum levels in dilated cardiomyopathy patients ［J］.J Card Fail，2007，13（10）： 850-854.
45	刘夕芳，李晓燕.S100β 水平与心功能及慢性心力衰竭的相关性研究［J/OL］.中西医结合心血管病电子杂志，2016，4（19）： 134-135.
46	任妍，虞莹珺，李金平，等.S100β 在慢性心力衰竭诊疗中的临床意义［J］.国际心血管病杂志，2012，39（6）： 385-388.
47	孙艳，王泽林，李博慧，等.S100B 水平与心功能及慢性心力衰竭的相关性研究［J］.中华老年医学杂志，2015，34（5）： 3.
48	Tsoporis JN，Overgaard CB，Izhar S，et al.S100B modulates the hemodynamic response to norepinephrine stimulation ［J］.Am J Hypertens，2009，22（10）： 1048-1053.
49	Gentil BJ，Delphin C，Mbele GO，et al.The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein：potential implications for Ca2+ homeostasis regulation by S100B ［J］.J Biol Chem，2001，276（26）： 23253-23261.
50	Zhou Y，Zha Y，Yang Y，et al.S100 proteins in cardiovascular diseases［J］.Mol Med，2023，29（1）： 68.
51	Reddy VY，Calkins H，Mansour M，et al.Pulsed field ablation to treat paroxysmal atrial fibrillation： safety and effectiveness in the ADMIRE pivotal trial ［J］.Circulation，2024，150（15）： 1174-1186.
52	Armour JA，Murphy DA，Yuan BX，et al.Gross and microscopic anatomy of the human intrinsic cardiac nervous system ［J］.Anat Rec，247（2）： 289-298.
53	Katritsis DG，Pokushalov E，Romanov A，et al.Autonomic denervation added to pulmonary vein isolation for paroxysmal atrial fibrillation ［J］.J Am Coll Cardiol，2013，62（24）： 2318-2325.
54	Mao J，Yin X，Zhang Y，et al.Ablation of epicardial ganglionated plexi increases atrial vulnerability to arrhythmias in dogs ［J］.Circ Arrhythm Electrophysiol，2014，7（4）： 711-717.
55	Sorci G，Bianchi R，Riuzzi F，et al.S100B protein，a damage-associated molecular pattern protein in the brain and heart and beyond ［J］.Cardiovasc Psychiatry Neurol，2010，2010： 656481.
56	Scherschel K，Hedenus K，Jungen C，et al.Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation［J］.Sci Transl Med，2019，11（493）： eaav7770.
57	刘旨浩，段首鹏，王钧，等.血清 S100β 水平对心房颤动导管消融术后复发的预测价值［J］.中国心血管杂志，2023，28（1）： 23-28.
58	Mazzini GS，Schaf DV，Vinadé ER，et al.Increased S100B serum levels in dilated cardiomyopathy patients ［J］.J Card Fail，2007，13（10）： 850-854.
59	任妍，虞莹珺，李金平，等.S100B 在慢性心力衰竭诊疗中的临床意义［J］.国际心血管病杂志，2012，39（6）： 385-388.
60	孙敏伊，黄燕，林更映.病毒性心肌炎患者血清钙卫蛋白A4、A8/A9 与病情及预后不良的关系［J］.武警医，2025，36（2）： 110-114.
61	符媛媛，胡猛，徐进辉，等.心脏瓣膜术后早期认知功能障碍的相关危险因素分析［J］.医学研究生学报，2017，30（5）： 515-520.
62	Yuan X，Wang J，Wang D，et al.NSE，S100B and MMP9 expression following reperfusion after carotid artery stenting ［J］.Curr Neurovasc Res，2019，16（2）： 129-134.
63	Imbalzano E，Quartuccio S，Casciaro M，et al.S100B in heart diseases［J］.Cardiovasc Pathol，2020，49： 107235.
64	Deye N，Nguyen P，Vodovar N，et al.Protein S100B as a reliable tool for early prognostication after cardiac arrest ［J］.Resuscitation，2020，156： 251-259.

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