Relationship between plasma level of long non-coding RNA51A and cognitive function in patients with Alzheimer′s disease

doi:10.3877/cma.j.issn.1674-0785.2018.02.007

Abstract

Abstract:

Objective

To examine the relationship between plasma level of long non-coding RNA 51A (lncRNA 51A) and the change in cognitive function in patients with Alzheimer′s disease (AD).

Methods

Plasma samples were obtained from 70 AD patients and 70 healthy controls from June 2014 to June 2017 at the Department of Neurology of the Jili Hospital of Liuyang and Nerve Medical Center of the First Hospital of Changsha. Plasma levels of lncRNA 51A were measured by real-time quantitative reverse transcriptase PCR (qRT-PCR) and compared between the two groups by the t-test. The correlation between the Mini Mental State Examination (MMSE) scores and the levels of plasma lncRNA 51A in AD patients was analyzed by Spearman correlation.

Results

Plasma lncRNA 51A level in AD patients was significantly higher than that in controls (t=30.74, P<0.001). Plasma lncRNA 51A was negatively correlated with the MMSE scores in AD patients (r=-0.204, P<0.001).

Conclusion

Plasma lncRNA 51A levels increase in AD patients. The degree of cognitive impairment in AD patients can be reflected by the level of plasma lncRNA 51A.

Key words: Long non-coding RNA 51A, Alzheimer′s disease, Cognitive function

Zheng Lyu, Yuzhang Bei, Guiwen Bu, Liang Deng, Le Xiao, Yanyao Deng. Relationship between plasma level of long non-coding RNA51A and cognitive function in patients with Alzheimer′s disease[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(02): 95-97.

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Figures/Tables 1

References 9

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组别	例数	性别（男/女）	年龄（岁）	教育时间（年）	BMI（kg/m²）	MMSE评分（分）
AD组	70	40/30	71.6±5.4	6.51±1.41	22.5±3.8	12.81±4.77
对照组	70	38/32	70.4±5.2	6.13±1.92	21.32±3.4	29.27±0.35
统计值	?	χ²=0.116	t=0.979	t=0.643	t=0.356	t=18.45
P值	?	0.865	0.199	0.375	0.573	<0.001

组别	例数	性别（男/女）	年龄（岁）	教育时间（年）	BMI（kg/m²）	MMSE评分（分）
AD组	70	40/30	71.6±5.4	6.51±1.41	22.5±3.8	12.81±4.77
对照组	70	38/32	70.4±5.2	6.13±1.92	21.32±3.4	29.27±0.35
统计值	?	χ²=0.116	t=0.979	t=0.643	t=0.356	t=18.45
P值	?	0.865	0.199	0.375	0.573	<0.001

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