Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Clinicians(Electronic Edition) ›› 2018, Vol. 12 ›› Issue (05): 302-305. doi: 10.3877/cma.j.issn.1674-0785.2018.05.009

Special Issue:

• Review • Previous Articles     Next Articles

Epigenetics of Graves disease

Alimu Adila1, Yanying Guo1, Xinling Wang1,()   

  1. 1. Department of Endocrinology, People′s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
  • Received:2017-11-15 Online:2018-03-01 Published:2018-03-01
  • Contact: Xinling Wang
  • About author:
    Corresponding author: Wang Xinling, Email:

Abstract:

Graves disease (GD), also known as toxic diffuse goiter, is the most common cause of hyperthyroidism. Recent studies have shown that the interaction between genetic susceptibility and environmental predisposing factors is possibly the key cause of GD, and epigenetics is a bridge between the environment and genetics. Evidence indicates that epigenetic changes including DNA methylation, histone covalent modification, and gene silencing mediated by non-coding RNA molecules play an important role in the pathogenesis of GD. This article mainly describes the epigenetics involved in the pathogenesis of GD and its potential clinical applications.

Key words: Graves disease, Epigenetics, DNA methylation, Histone modifications, MicroRNA

京ICP 备07035254号-20
Copyright © Chinese Journal of Clinicians(Electronic Edition), All Rights Reserved.
Tel: 010-57830845 E-mail: zhlcyszz@cma.org.cn
Powered by Beijing Magtech Co. Ltd