Quantitative assessment of correction between programmed cell death -1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in Chinese population

doi:10.3877/cma.j.issn.1674-0785.2018.05.011

Abstract

Abstract:

Objective

To assess the association between the programmed cell death-1 (PD-1) polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population.

Methods

We searched PubMed, MEDLINE, and CNKI databases and retrieved studies (2536 cases and 3491 controls) on the association of PD-1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population. Meta-analysis was performed with Stata statistical package 12.0, with 95% confidence intervals and odds ratios calculated.

Results

Meta-analysis of all the included clinical trials showed that there was no significant association between the PD-1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population in all the genetic models [homozygous (GG vs AA: OR=0.81, 95%CI=0.58~1.15, P=0.236); heterozygous (AG vs AA: OR=0.97, 95%CI=0.87~1.08, P=0.523); dominant (AG+ GG vs AA: OR=0.95, 95%CI=0.86~1.05, P=0.333); recessive (GG vs AG+ AA: OR=0.82, 95%CI=0.58~1.16, P=0.263); and allele (T vs C: OR=0.95, 95%CI=0.88~1.03, P=0.211)].

Conclusion

There was no significant association between the PD-1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population.

Key words: Programmed cell death-1, Polymorphism, Upper digestive tract cancer, Risk, Correlation analysis

Yuetao Zhao, Xiaoming Zheng, Zhiyong Yu, Pei Qin, Chunben Xu. Quantitative assessment of correction between programmed cell death -1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in Chinese population[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(05): 310-314.

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Figures/Tables 5

References 15

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研究者	年份	肿瘤类型	人群国籍	例数（病例组/对照组）	匹配标准	对照人群来源	基因分型方法	是否符合HWE
Qiu等^[9]	2014	食管癌	中国	629/686	年龄、性别	医院来源	PCR-LDR	符合
Tang等^[10]	2015	胃贲门腺癌	中国	330/608	年龄、性别	医院来源	PCR-LDR	符合
Zhou等^[11]	2016	食管鳞状细胞癌	中国	584/585	年龄、性别	内镜普查	PCR-LDR	符合
Tang等^[12]	2017	食管胃交界腺癌	中国	1063/1677	年龄、性别	健康体检	SNPscanTM	符合

研究者	年份	肿瘤类型	人群国籍	例数（病例组/对照组）	匹配标准	对照人群来源	基因分型方法	是否符合HWE
Qiu等^[9]	2014	食管癌	中国	629/686	年龄、性别	医院来源	PCR-LDR	符合
Tang等^[10]	2015	胃贲门腺癌	中国	330/608	年龄、性别	医院来源	PCR-LDR	符合
Zhou等^[11]	2016	食管鳞状细胞癌	中国	584/585	年龄、性别	内镜普查	PCR-LDR	符合
Tang等^[12]	2017	食管胃交界腺癌	中国	1063/1677	年龄、性别	健康体检	SNPscanTM	符合

作者	年份	肿瘤类型	病例组基因分布					对照组基因分布					样本量（病例组/对照组）
作者	年份	肿瘤类型	AA	AG	GG	A	G	AA	AG	GG	A	G	样本量（病例组/对照组）
Qiu等^[9]	2014	食管癌	317	240	43	874	326	345	243	63	933	369	600/651
Tang等^[10]	2015	胃贲门腺癌	169	123	21	461	165	309	219	53	837	325	313/581
Zhou等^[11]	2016	食管鳞状细胞癌	325	226	33	876	292	296	238	51	830	340	584/585
Tang等^[12]	2017	食管胃交界腺癌	544	397	98	1485	593	870	672	132	2412	936	1039/1674

作者	年份	肿瘤类型	病例组基因分布					对照组基因分布					样本量（病例组/对照组）
作者	年份	肿瘤类型	AA	AG	GG	A	G	AA	AG	GG	A	G	样本量（病例组/对照组）
Qiu等^[9]	2014	食管癌	317	240	43	874	326	345	243	63	933	369	600/651
Tang等^[10]	2015	胃贲门腺癌	169	123	21	461	165	309	219	53	837	325	313/581
Zhou等^[11]	2016	食管鳞状细胞癌	325	226	33	876	292	296	238	51	830	340	584/585
Tang等^[12]	2017	食管胃交界腺癌	544	397	98	1485	593	870	672	132	2412	936	1039/1674

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