Advances in treatment of sepsis using mesenchymal stem cells

doi:10.3877/cma.j.issn.1674-0785.2018.09.009

Abstract

Abstract:

Sepsis is a life-threatening syndrome. The host immune response to microbial infection is critical, with early-phase sepsis characterized by a hyperinflammatory immune response, whereas the later phase of sepsis is often complicated by immunosuppression. Stem cells constitute promising therapeutic agents for sepsis. We examine the rationale for stem cells in the treatment of sepsis, focusing on mesenchymal stem/stromal cells, which currently demonstrate the greatest therapeutic promise.

Key words: Sepsis, Mesenchymal stem cells

Jilin Yang, Xianzheng Wu. Advances in treatment of sepsis using mesenchymal stem cells[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(09): 525-529.

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References 48

1	张庆红，姚咏明. 严重脓毒症与免疫功能障碍[J]. 医学与哲学, 2014, 35(2):18-22.
2	Angus DC. van der Poll T: Severe sepsis and septic shock[J]. N Engl J Med, 2013, 369:840-851.
3	刘大为. Sepsis-3还告诉了我们什么? [J] 中华危重病急救医学, 2017, 29(2):97-98.
4	Pisetsky DS.The origin and properties of extracellular DNA: From PAMP to DAMP[J]. Clin Immunol, 2012, 144:32-40.
5	Boomer JS, Green JM. Hotchkiss RS: The changing immune system in sepsis[J]. Is individualized immuno-modulatory therapy the answer Virulence, 2014, 5:45-56.
6	Hotchkiss RS. Karl IE: The pathophysiology and treatment of sepsis[J]. N Engl J Med, 2003, 348:138-150.
7	Kumar A.Kethireddy S: Emerging concepts in optimizing antimicrobial therapy of septic shock: Speed is life but a hammer helps too[J]. Crit Care, 2013, 17:104.
8	Martin GS, Mannino DM, Eaton S. The epidemiology of sepsis in the United States from 1979 through 2000[J]. N Engl J Med, 2003, 348:1546-1554.
9	Boomer JS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure[J]. JAMA, 2011, 306:2594-2605.
10	Hall MW, Knatz NL, Vetterly C, et al. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome[J]. Intensive Care Med, 2011, 37:525-532.
11	Otto GP, Sossdorf M, Claus RA, et al. The late phase of sepsis is characterized by an increased microbiological burden and death rate[J]. Crit Care, 2011, 15:R183.
12	van Vught LA, Klein Klouwenberg PM, Spitoni C, et al.MARS Consortium: Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis[J]. JAMA, 2016, 315:1469-1479.
13	Angus DC: The search for effective therapy for sepsis: Back to the drawing board? [J] JAMA, 2011, 306:2614-2615.
14	Cohen J, Opal S, Calandra T. Sepsis studies need new direction[J]. Lancet Infect Dis, 2012, 12:503-505.
15	Curley GF, Hayes M, Ansari B, et al. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat[J]. Thorax, 2012, 67:496-501.
16	Curley GF, Ansari B, Hayes M, et al.Effects of intratracheal mesenchymal stromal cell therapy during recovery and resolution after ventilator-induced lung injury[J]. ANESTHESIOLOGY, 2013, 118:924-932.
17	Hayes M, Masterson C, Devaney J, et al. Therapeutic efficacy of human mesenchymal stromal cells in the repair of established ventilator-induced lung injury in the rat[J]. ANESTHESIOLOGY, 2015, 122:363-373.
18	Krasnodembskaya A, Song Y, Fang X, et al. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37 Stem Cells[J]. 2010, 28:2229-2238.
19	Gupta N, Su X, Popov B,et al. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin induced acute lung injury in mice J[J]. Immunol, 2007, 179:1855-1863.
20	Lee JW FX, Gupta N, Serikov V, et al. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci USA, 2009, 106:6.
21	Wilson JG, Liu KD, Zhuo H, et al. Matthay MA: Mesenchymal stem (stromal) cells for treatment of ARDS: A phase 1 clinical trial[J]. Lancet Respir Med, 2015, 3:24-32.
22	Zhu YG FX, Abbott J, Fang XH, et al. Lee JW: Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxininduced acute lung injury in mice[J]. Stem Cells, 2014, 32:10.
23	Gupta N, Krasnodembskaya A, Kapetanaki M, et al. Matthay MA: Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia colipneumonia[J]. Thorax, 2012, 67:533-539.
24	Shalaby SM, El-Shal AS, Abd-Allah SH, et al. Abdelazim S: Mesenchymal stromal cell injection protects against oxidative stress in Escherichia coli-induced acute lung injury in mice[J]. Cytotherapy, 2014, 16:764-775.
25	Devaney J, Horie S, Masterson C, et al. Laffey JG: Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E[J]. coli in the rat. Thorax, 2015, 70:625-635.
26	Krasnodembskaya A, Samarani G, Song Y, et al. Matthay MA: Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes[J]. Am J Physiol Lung Cell Mol Physiol, 2012, 302:L1003-1013.
27	Sutton MT, Fletcher D, Ghosh SK, et al. Bonfield TL: Antimicrobial properties of mesenchymal stem cells: Therapeutic potential for cystic fibrosis infection, and treatment[J]. Stem Cells Int, 2016, 5303048.
28	Yuan Y, Lin S, Guo N, et al. Ye H: Marrow mesenchymal stromal cells reduce methicillin-resistant Staphylococcus aureus infection in rat models[J]. Cytotherapy, 2014, 16:56-63.
29	Guerra AD, Cantu DA, Vecchi JT, et al. Kao WJ: Mesenchymal stromal/stem cell and minocycline-loaded hydrogels inhibit the growth of staphylococcus aureus that evades immunomodulation of blood-derived leukocytes[J]. AAPS J, 2015, 17:620-630.
30	Monsel A, Zhu YG, Gennai S, et al. Lee JW: Therapeutic effects of human mesenchymal stem cell-derived microvesicles in severe pneumonia in mice[J]. Am J Respir Crit Care Med, 2015, 192:324-336.
31	Mei SH, Haitsma JJ, Dos Santos CC, et al. Stewart DJ: Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis[J]. Am J Respir Crit Care Med, 2010, 182:1047-1057.
32	Németh K, Leelahavanichkul A, Yuen PS, et al. Mezey E: Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin
33	dos Santos CC, Murthy S, Hu P, et al. Liles WC: Network analysis of transcriptional responses induced by mesenchymal stem cell treatment of experimental sepsis[J]. Am J Pathol, 2012, 181:1681-1692.
34	Weil BR, Herrmann JL, Abarbanell AM, et al. Meldrum DR: Intravenous infusion of mesenchymal stem cells is associated with improved myocardial function during endotoxemia[J]. Shock, 2011, 36:235-241.
35	Martinon F, Burns K. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta[J]. Mol Cell, 2002, 10:417-426.
36	Miao CM, Jiang XW, He K, et al. Bone marrow stromal cells attenuate LPS-induced mouse acute liver injury via the prostaglandin E 2-dependent repression of the NLRP3 inflammasome in Kupffer cells[J]. Immunol Lett, 2016, 179:102-113.
37	Kolaczkowska E,. Kubes P: Neutrophil recruitment and function in health and inflammation[J]. Nat Rev Immunol, 2013, 13:159-175.
38	Mei SH, Haitsma JJ, Dos Santos CC, et al.Stewart DJ: Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis[J]. Am J Respir Crit Care Med, 2010, 182:1047-1057.
39	Chao YH, Wu HP, Wu KH, et al. Fu YC: An increase in CD3＋CD4＋CD25＋ regulatory T cells after administration of umbilical cord-derived mesenchymal stem cells during sepsis[J]. PLoS One, 2014, 9:e110338.
40	Ghannam S, Pène J, Moquet-Torcy G, et al. Yssel H: Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype[J]. J Immunol, 2010, 185:302-312.
41	Duffy MM, Ritter T, Ceredig R.Griffin MD: Mesenchymal stem cell effects on T-cell effector pathways[J]. Stem Cell Res Ther, 2011, 2:34.
42	Krampera M, Cosmi L, Angeli R, et al.Annunziato F: Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells[J]. Stem Cells, 2006, 24:386-398.
43	DelaRosa O, Sánchez-Correa B, Morgado S, et al.Casado JG: Human adipose-derived stem cells impair natural killer cell function and exhibit low susceptibility to natural killermediated lysis[J]. Stem Cells Dev, 2012, 21:1333-1343.
44	Belkaid Y. Tarbell K: Regulatory T cells in the control of host-microorganism interactions[J]. Annu Rev Immunol, 2009, 27:551-589.
45	Sun J, Han ZB, Liao W, et al. Han ZC: Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute lung injury by expanding CD4＋CD25＋ Forkhead Boxp3 (FOXP3)＋ regulatory T cells and balancing anti- and pro-inflammatory factors[J].Cell Physiol Biochem, 2011, 27:587-596.
46	Heuer JG, Zhang T, Zhao J, et al. Na S: Adoptive transfer of in vitro-stimulated CD4＋CD25＋ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis[J]. J Immunol, 2005, 174:7141-7146.
47	Xu G, Zhang L, Ren G, et al. Shi Y: Immunosuppressive properties of cloned bone marrow mesenchymal stem cells[J]. Cell Res, 2007, 17:240-248.
48	Islam MN, Das SR, Emin MT, et al. Bhattacharya J: Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury[J]. Nat Med, 2012, 18:759-765.

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