Association between peripheral blood levels of 25(OH)D and hypersensitive C-reactive protein in patients with inflammatory and non-inflammatory diseases

doi:10.3877/cma.j.issn.1674-0785.2019.06.010

Abstract

Abstract:

Objective

To investigate the correlation between peripheral blood levels of 25-hydroxyvitamin D [25(OH)D] and hypersensitive C-reactive protein (hs-CRP) in patients with inflammatory and non-inflammatory diseases.

Methods

A total of 281 patients (130 patients with inflammatory disease and 151 cases with non-inflammatory disease) were involved in this study between September 2017 and November 2017. The levels of 25(OH)D and hs-CRP in peripheral blood were detected by electrochemiluminescence and turbidimetry, respectively.

Results

The levels of 25(OH)D in the inflammatory disease group were significantly negatively correlated with those of hs-CRP (r=-0.780, P<0.001). In the non-inflammatory disease group, the 25(OH)D levels and hs-CRP concentrations had a weaker negative association (r=-0.636, P<0.001).

Conclusion

Peripheral blood levels of 25(OH)D are negatively associated with hs-CRP not only in patients with inflammatory disease but also in non-inflammatory populations. The correlation in the inflammatory group is significantly higher than that in the non-inflammatory group.

Key words: High-sensitivity, 25-hydroxy vitamin D, Inflammatory disease, Inflammatory

Liying Zhou, Li Jiang. Association between peripheral blood levels of 25(OH)D and hypersensitive C-reactive protein in patients with inflammatory and non-inflammatory diseases[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(06): 454-456.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2019.06.010

https://zhlcyszz.cma-cmc.com.cn/EN/Y2019/V13/I06/454

Figures/Tables 2

References 10

1	Albert PJ, Proal AD, Marshalt TG. Vitamin D:the alternative hypothesis [J]. Autoimmun Rev, 2009, 8(8): 639-644.
2	Zakeri Z, Sandoughi M, Mashhadi MA, et al. Serum vitamin D level and disease activity in patients with recent onset rheumatoid arthritis [J]. Int J Rheum Dis, 2016, 19(4): 343-347.
3	Torki M, Gholamregaei A, Mirbagher L, et al. Vitamin D deficiency association with disease activity in patients with inflammatory bowel diseases [J]. Dig Dis Sci, 2015, 60(10): 3085-3091.
4	Devaraj S, Jialal G, Cook T, et al. Low Vitamin D levels in northern American adults with the metabolic syndrome [J]. Horm Metab Res, 2011, 43(1): 72-74.
5	Amer M, Qayyum R. Relation between Serum 25-hydroxyvitamin D and C-reactive protein in saymptomatic adults [J]. Am J Cardiol, 2012, 109(2): 226-230.
6	Melleuthin L, Wallaschofski H, Grotevendt A, et al. Association between Serum Vitamin D concentration and inflammatory markers in the general adult population [J]. Metab Clin Exp, 2014, 63(8): 1056-1062.
7	Kambis Sadeghi, Barhara Wessner, Ute laggner, et al. Vitamin D3 down-regulated monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns [J]. Eur J Immunol, 2006, 36(2): 361-370.
8	袁北芳，任立红. 维生素D及其受体的免疫调节作用研究进展 [J]. 国际免疫学杂志, 2014, 37(1): 52-56.
9	Hewison M. An update on Vitamin D and human immunity [J]. Clin Endocrinol, 2012, 76(3): 315-325.
10	Chen N, Wan Z, Han SF, et al. Effect of Vitamin D Supplementation on the circulating high-sensitivity C-reactive protein;a meta-analysis of randomiged controlled trails [J]. Nutrients, 2014, 6(6): 2206-2216.

[1]	Yue Zhang. Diagnosis and treatment of neck pain caused by transient perivascular inflammation of the carotid artery [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(05): 336-339.
[2]	Yanli Liu, Yongjin Chen. Prognosis assessment and treatment measures for permanent tooth trauma with root fracture [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(05): 295-299.
[3]	Chengwang Fu, Dagang Yang, Rong Wang, Futang Li. Research progress of nutritional and inflammatory markers in resectable pancreatic cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(06): 704-708.
[4]	Yixiao Tang, Jun Chen, Zhengxing Lian, HaiTao Hu, Di Lu, Xiao Xu, Qiang Wei. Study on the protective effect of bilobalide on hepatic ischemia-reperfusion injury in mice [J]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(05): 278-282.
[5]	Hua Wang, Su'e Cao, Jianjie Wu, Jinming Di. Diagnosis and treatment of inflammatory myofibroblastic tumor of urinary bladder: report of four cases and literature review [J]. Chinese Journal of Endourology(Electronic Edition), 2024, 18(06): 547-552.
[6]	Guiwei Du, Yong Lu, Bo Cheng, Yi He, Shuang Liang. Analysis of the effect of combined tamsulosin therapy on patients with ureteral calculus after holmium laser lithotripsy [J]. Chinese Journal of Endourology(Electronic Edition), 2024, 18(05): 491-496.
[7]	Juan Gao, Jianqing Xu, Fang Yan, Shenghua Ding, Xia Liu. Clinical effects of Rutkow, TAPP, and TEP in the treatment of patients with unilateral inguinal hernia and their impact on serum inflammatory factor levels [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(06): 675-680.
[8]	Jiayi Xing, Jiasheng Gong, Jiajia Zhu, Qun Lu. Analysis of pathogenic drug resistance and inflammatory factor changes in secondary pulmonary infection in chemotherapy patients with lung cancer [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2024, 17(05): 714-718.
[9]	Li Chen, Changqing Yang, Fengshang Zhu. Strengthen the investigation of the cross-talk mechanism between inflammatory bowel disease and metabolic dysfunction-associated steatotic liver disease [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(05): 385-389.
[10]	Li Cong, Lin Ma, Xu Chen, Wenwen Li, Liangliang Zhang, Huating Zhou. MCTSI and detection of serum inflammatory factors in the prediction of pancreatic infection and prognosis evaluation of severe acute pancreatitis [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(05): 432-436.
[11]	Na Tian, Feitian Han. Establishment of a model for predicting the recurrence of acute pancreatitis based on CT plain scan imaging group model and systemic immune inflammatory index [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(04): 355-359.
[12]	Xiuling Li, Shaofeng Lian, LiuTao Rong, Dengfeng Li, Yunyu Rao. Clinical study of ribavirin combined with compound lactobacillus acidophilus in the treatment of children with rotavirus enteritis [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(04): 369-372.
[13]	Zhan Wang, Wenkun Li, Yi Yang, Fang Xu, Minsi Zhou, Jiayi Su, Yadan Wang, Jing Wu. Application of inflammatory markers in early-onset colorectal tumors [J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(09): 802-810.
[14]	Chunying Ou, Xiaobin Li, Jing Guo, Liang Zhu, Ke Xu, Meng Wang, Xiaolei An. Effects of butylphthalide on inflammatory factors and improvement of learning and memory in rats with vascular cognitive impairment [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(05): 483-487.
[15]	Lei Mou, Dongcheng Xu, Xin Han, Changjiang Xu, Kunqi Han, Yexiao Xue, Yuan Mou, Wenling Qin, Xiangjing Liu, Xiangjing Liu, Nan Gao. Study on prevention and treatment of restenosis after vertebrobasilar artery stenting with Wuchong Tongluo Capsule [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(05): 467-472.

Please choose a citation manager

Content to export