Progress in methylene blue mediated photodynamic therapy for infection-related skin diseases

doi:10.3877/cma.j.issn.1674-0785.2019.09.012

Abstract

Abstract:

Methylene blue belongs to a phenothiazine derivative that is a commonly used photosensitizer in photodynamic therapy (PDT). In vitro studies have confirmed that methylene blue mediated photodynamic therapy (MB-PDT) has significant inhibitory or killing effects on numerous pathogens like bacteria, fungi, viruses, and protists. In recent years, clinical studies on MB-PDT treatment for infection-associated skin diseases have gradually increased, and shown therapeutic effect on a variety of infection-associated skin diseases. Compared with other photosemsitizers, MB-PDT has less adverse reactions, lower prices, and good application prospects.

Key words: Methylene blue, Photodynamic therapy, Infection-related skin disease

Chanchan Li, Jianbo Wu. Progress in methylene blue mediated photodynamic therapy for infection-related skin diseases[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(09): 698-701.

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