Association of simple insulin resistance index with hyperuricemia in normal-weight individuals

doi:10.3877/cma.j.issn.1674-0785.2020.10.011

Abstract

Abstract:

Objective

To explore the relationship between simple insulin resistance (IR) assessment tools and hyperuricemia (HUA) in normal-weight people.

Methods

A total of 11098 people with a normal body weight who underwent a physical examination at Jingjiang People's Hospital Affiliated to Yangzhou University School of Medicine from August 2016 to December 2019 were included. The triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C), product of fasting triglycerides and glucose (TyG), and metabolic score for IR (METS-IR) were calculated by the corresponding formula. Partial correlation analysis and logistic regression model were used to analyze the correlation between continuous and categorical variables.

Results

TG/HDL-C, TyG, and METS-IR were significantly correlated with uric acid levels; the mean values of the three IR indicators in the HUA group were significantly higher than those of the normal group, and the proportion of patients with HUA increased significantly with the increase of the interquartile range (Q) of the three IR indicators. Regression analysis showed that only TyG and METS-IR were significantly associated with HUA; the odds ratio (OR) values of Q₄ of TyG were 1.665 (95% CI: 1.147-2.418) for men and 2.894 (95% CI: 1.486-5.637) for women; the OR values of Q₄ of METS-IR were 2.172 (95% CI: 1.670-2.826) for men and 1.997 (95% CI: 1.107-3.603) for women.

Conclusion

TyG and METS-IR are robustly associated with HUA in non-obese individuals, which are expected to be used as a classification management tool for normal-weight HUA patients.

Key words: Hyperuricemia, Normal weight, Insulin resistance

Jianqin Zhu, Guoqing Li, Yi Miao. Association of simple insulin resistance index with hyperuricemia in normal-weight individuals[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(10): 808-812.

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Figures/Tables 4

References 23

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组别	例数	年龄（岁）	体质量指数（kg/m²）	腰围（cm）	收缩压（mmHg）	舒张压（mmHg）	空腹血糖（mmol/L）	尿酸（μmol/L）
尿酸正常组	5675	44.2±13.0	21.9±1.6	77.3±5.8	126.9±6.3	77.7±6.6	5.56±1.16	337.6±48.1
HUA组	1361	45.0±13.5	22.4±1.4	79.4±5.4	126.6±6.5	78.7±6.4	5.43±0.78	470.0±45.4
t值		-1.905	-11.201	-11.392	1.553	-5.034	3.953	-92.119
P值		0.057	＜0.001	＜0.001	0.120	＜0.001	＜0.001	＜0.001
组别	例数	总胆固醇（mmol/L）	TG（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	TG/HDL-C	TyG	METS-IR
尿酸正常组	5675	4.61±0.82	1.29±0.86	1.53±0.32	2.64±0.71	0.93±0.86	8.50±0.53	30.99±3.73
HUA组	1361	4.80±0.93	1.73±1.29	1.46±0.29	2.70±0.79	1.30±1.24	8.74±0.59	32.60±3.58
t值		-7.783	-15.192	7.356	-2.731	-12.724	-14.553	-14.413
P值		＜0.001	＜0.001	＜0.001	0.006	＜0.001	＜0.001	＜0.001

组别	例数	年龄（岁）	体质量指数（kg/m²）	腰围（cm）	收缩压（mmHg）	舒张压（mmHg）	空腹血糖（mmol/L）	尿酸（μmol/L）
尿酸正常组	5675	44.2±13.0	21.9±1.6	77.3±5.8	126.9±6.3	77.7±6.6	5.56±1.16	337.6±48.1
HUA组	1361	45.0±13.5	22.4±1.4	79.4±5.4	126.6±6.5	78.7±6.4	5.43±0.78	470.0±45.4
t值		-1.905	-11.201	-11.392	1.553	-5.034	3.953	-92.119
P值		0.057	＜0.001	＜0.001	0.120	＜0.001	＜0.001	＜0.001
组别	例数	总胆固醇（mmol/L）	TG（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	TG/HDL-C	TyG	METS-IR
尿酸正常组	5675	4.61±0.82	1.29±0.86	1.53±0.32	2.64±0.71	0.93±0.86	8.50±0.53	30.99±3.73
HUA组	1361	4.80±0.93	1.73±1.29	1.46±0.29	2.70±0.79	1.30±1.24	8.74±0.59	32.60±3.58
t值		-7.783	-15.192	7.356	-2.731	-12.724	-14.553	-14.413
P值		＜0.001	＜0.001	＜0.001	0.006	＜0.001	＜0.001	＜0.001

组别	例数	年龄（岁）	体质量指数（kg/m²）	腰围（cm）	收缩压（mmHg）	舒张压（mmHg）	空腹血糖（mmol/L）	尿酸（μmol/L）
尿酸正常组	3821	52.4±11.8	21.8±1.6	73.5±5.5	124.4±9.6	74.8±8.3	5.81±1.21	282.3±51.3
HUA组	241	47.2±12.8	22.2±1.4	74.2±5.7	122.3±10.4	75.7±8.2	5.75±0.69	415.5±49.7
t值		6.650	-3.413	-1.768	3.219	-1.723	0.73	-39.139
P值		＜0.001	0.001	0.077	0.001	0.085	0.466	＜0.001
组别	例数	总胆固醇（mmol/L）	TG（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	TG/HDL-C	TyG	METS-IR
尿酸正常组	3821	5.21±0.97	1.78±0.85	1.54±0.32	2.78±0.80	1.25±1.01	8.94±0.35	31.67±3.39
HUA组	241	5.21±0.99	2.14±1.25	1.46±0.28	2.70±0.83	1.61±1.32	9.08±0.43	32.98±3.49
t值		0.068	-6.141	3.884	1.404	-5.177	-6.036	-5.821
P值		0.945	＜0.001	＜0.001	0.16	＜0.001	＜0.001	＜0.001

组别	例数	年龄（岁）	体质量指数（kg/m²）	腰围（cm）	收缩压（mmHg）	舒张压（mmHg）	空腹血糖（mmol/L）	尿酸（μmol/L）
尿酸正常组	3821	52.4±11.8	21.8±1.6	73.5±5.5	124.4±9.6	74.8±8.3	5.81±1.21	282.3±51.3
HUA组	241	47.2±12.8	22.2±1.4	74.2±5.7	122.3±10.4	75.7±8.2	5.75±0.69	415.5±49.7
t值		6.650	-3.413	-1.768	3.219	-1.723	0.73	-39.139
P值		＜0.001	0.001	0.077	0.001	0.085	0.466	＜0.001
组别	例数	总胆固醇（mmol/L）	TG（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	TG/HDL-C	TyG	METS-IR
尿酸正常组	3821	5.21±0.97	1.78±0.85	1.54±0.32	2.78±0.80	1.25±1.01	8.94±0.35	31.67±3.39
HUA组	241	5.21±0.99	2.14±1.25	1.46±0.28	2.70±0.83	1.61±1.32	9.08±0.43	32.98±3.49
t值		0.068	-6.141	3.884	1.404	-5.177	-6.036	-5.821
P值		0.945	＜0.001	＜0.001	0.16	＜0.001	＜0.001	＜0.001

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