To evaluate the effect of 1-hour bundle on the prognosis in patients with septic shock.

A prospective, multi-center, cohort clinical study was performed, in which patients with septic shock at the Department of Intensive Medicine of Jiangdu People's Hospital and Subei People's Hospital were consecutively treated from January 2018 to December 2019. According to whether to complete the 1-hour bundle, the patients were divided into either a 1-hour bundle group or a control group. The prognostic indicators were compared between the two groups. The primary endpoint was 28-day mortality. The secondary endpoints were time to completion of sepsis therapy, mechanical ventilation time, and intensive care unit (ICU) stay.

A total of 332 patients with septic shock were included in the study, of whom 91 completed the 1-hour bundle, with a completion rate of only 27.4%. There were 241 patients (72.6%) who did not complete the 1-hour bundle. The 28-day mortality rate (43.9%) in the 1-hour bundle group was significantly lower than that in the control group (58.9%; P＜0.05). The number of days of ICU stay in the 1-hour bundle group (7.2±2.9) was lower than that in the control group (7.7±3.3), but there was no statistical difference.

Completion of 1-hour bundle can reduce the mortality of patients with septic shock, but the compliance of medical staff with 1-hour bundle is low. In the future, efforts should be made to improve medical staff's compliance with 1-hour bundle of septic shock.