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Chinese Journal of Clinicians(Electronic Edition) ›› 2021, Vol. 15 ›› Issue (07): 520-525. doi: 10.3877/cma.j.issn.1674-0785.2021.07.008

• Clinical Research • Previous Articles     Next Articles

Clinical efficacy and safety of Dingqing Tablets combined with Prescription of Invigorating Spleen and Kidney, Detoxification and Vigoration of Blood Circulation in treatment of myelodysplastic syndrome

Yuehong Pu1,(), Jiahui Lu2, Qing Zeng3, Jie Wang3   

  1. 1. Department of Emergency Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
    2. Department of Hematology, Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China
    3. Department of Hematology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
  • Received:2021-04-27 Online:2021-07-15 Published:2021-11-09
  • Contact: Yuehong Pu

Abstract:

Objective

To observe the clinical efficacy and safety of Dingqing Tablets combined with Prescription of Invigorating Spleen and Kidney, Detoxification and Vigoration of Blood Circulation in the treatment of myelodysplastic syndrome (MDS).

Methods

Sixty patients with MDS and TCM syndrome of spleen and kidney deficiency, stasis and toxin internal accumulation diagnosed at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine from May 2012 to April 2013 were selected and randomly divided into a treatment group and a control group, with 30 cases in each group. The patients in the control group were treated with Testosterone Undecanoate, Thalidomide, or Cyclosporine, combined with Prescription of Invigorating Spleen and Kidney, Detoxification and Vigoration of Blood Circulation, or combined with DA or CAG chemotherapy if necessary. Patients in the treatment group were treated with Dingqing Tablets combined with Prescription of Invigorating Spleen and Kidney, Detoxification and Vigoration of Blood Circulation. After 3 months of medication, the clinical efficacy of TCM and Western medicine, and the adverse reactions of the two groups were compared.

Results

In terms of the efficacy for Western medicine, in the treatment group there were 8 cases of partial remission, 11 cases of disease improvement, and 11 cases of ineffectiveness, with an effective rate of 63.4%; in the control group, there were 12 cases of partial remission, 10 cases of disease improvement, and 8 cases of ineffectiveness, with an effective rate of 73.2%. The effective rate did not differed statistically between the two groups (P>0.05). In terms of the efficacy for TCM syndrome, in the treatment group, there were 3 cases of remarkable improvement, 17 cases of improvement, 9 cases of ineffectiveness, and 1 case of aggravation, with a total effective rate of 66.7%; in the control group, there was no case of remarkable improvement, 7 cases of improvement, 15 cases of ineffectiveness, and 8 case of aggravation, with a total effective rate of 11.7%. The total effective rate of the treatment group was statistically significant higher than that of the control group (P<0.05). The incidence of abnormal liver and kidney function in the treatment group was significantly lower than that of the control group (6.7% vs 30.0%, P<0.05).

Conclusion

The clinical efficacy of Dingqing Tablets combined with Prescription of Invigorating Spleen and Kidney, Detoxification and Vigoration of Blood Circulation in the treatment of MDS is equivalent to that of conventional Western medicine combined with Prescription of Invigorating Spleen and Kidney, Detoxification and Vigoration of Blood Circulation, but the curative effect on TCM syndrome is obviously better. Although the two treatments are both safe, Dingqing Tablets combined with Prescription of Invigorating Spleen and Kidney, Detoxification and Vigoration of Blood Circulation for MDS treatment has a better safety profile.

Key words: Myelodysplastic syndrome, Dingqing Tablets, Prescription of Invigorating Spleen and Kidney, Detoxification and Vigoration of Blood Circulation, Clinical efficacy, Safety

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