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Chinese Journal of Clinicians(Electronic Edition) ›› 2021, Vol. 15 ›› Issue (09): 652-659. doi: 10.3877/cma.j.issn.1674-0785.2021.09.003

• Clinical Research • Previous Articles     Next Articles

Relationship between multimodal ultrasound characteristics and clinicopathological features of invasive breast cancer

Hong Zhang1,(), Li Qin1, Chunhong Lin1, Qiuju Wei1, Yanmei Miao1   

  1. 1. Department of Ultrasound, Hengshui People's Hospital, Hengshui 053000, China
  • Received:2021-04-09 Online:2021-09-15 Published:2022-01-20
  • Contact: Hong Zhang

Abstract:

Objective

To investigate the relationship between multimodal ultrasound characteristics and clinicopathological features of invasive breast cancer.

Methods

A total of 116 patients with invasive breast cancer admitted to Hengshui People's Hospital from June 2017 to September 2020 were selected retrospectively. Preoperative two-dimensional gray-scale, color Doppler flow imaging, shear wave elastic imaging and contrast-enhanced ultrasound examination were performed, and clinicopathological data were collected. The differences of multimodal ultrasound characteristics in patients with invasive breast cancer with different pathological features were identified.

Results

The difference of boundary burr and microcalcification between different histological types was significant (P<0.05). Infiltrating ductal carcinoma showed microcalcification, and infiltrating lobular carcinoma showed burr at the margin. Comparison of ultrasound elastography parameters showed that the shear wave elastic-ratio (SWE-Ratio) of invasive lobular carcinoma was higher than those of ductal carcinoma and others (6.35±2.59 vs 5.02±1.94 and 5.12±1.83, P<0.05). The blood supply grade and lymph node metastasis rate differed significantly between patients with different histology grades (P<0.05); the blood supply of patients with grade 3 histology was mainly grade 2-3 (57.35%), and the lymph node metastasis rate (55.56%) was significantly increased. Comparison of ultrasound elastography parameters showed that the maximum value of Young's elastic modulus (Emax), SWE-Ratio and the peak intensity (IMAX) of the lesion were higher in grade 3 histology than in grade 2 and grade 1 (P<0.05), while the Emax, SWE-Ratio, and IMAX in grade 2 were significantly higher than those in grade 1 [Emax: (223.35±65.35) kpa vs (199.35±53.78) kpa vs (146.43±35.49) kpa; SWE-Ratio: 7.15±3.61 vs 5.03±2.34 vs 2.70±1.05; IMAX: (139.35±24.65)% vs (124.35±19.35)% vs (81.67±13.05)%, P<0.05]. The detection rate of burr signs in ER and PR positive patients was lower than that in ER and PR negative patients (16.42% vs 85.07%, 23.88% vs 76.12%, P<0.05 each). The detection rate of microcalcification and posterior echo attenuation in Ki-67 positive patients was higher than that in Ki-67 negative patients (77.78%% vs 22.22%, 76.00% vs 24.00%, P<0.05 each), and the ratio of blood supply grade 2-3 in Ki-67 and HER-2 positive patients was higher than that in Ki-67 and HER-2 negative patients (60.29% vs 39.71%; 73.53% vs 16.47%, P<0.05). The SWE-Ratio of Ki-67 positive patients was higher than that of Ki-67 negative patients (6.06±2.05 vs 4.46±1.75, P<0.05), IMAX of HER-2 positive patients was higher than that of HER-2 negative patients [(136.35±21.35)% vs (102.35±16.35)%, P<0.05)], and time to peak was lower than that of HER-2 negative patients [(8.12±2.35) s vs (12.64±3.56) s, P<0.05].

Conclusion

The multimodal ultrasound characteristics are different among invasive breast cancer patients with different tissue types, grades, and ER, PR, HER-2, Ki-67 expression, and multimodal ultrasound can provide reference for clinical diagnosis and molecular typing evaluation.

Key words: Invasive breast cancer, Multimodal image, Shear wave elastography, Contrast-enhanced ultrasound, Color Doppler

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