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Chinese Journal of Clinicians(Electronic Edition) ›› 2024, Vol. 18 ›› Issue (01): 7-10. doi: 10.3877/cma.j.issn.1674-0785.2024.01.002

• Clinical Research • Previous Articles    

Pupil-dilating effects of different administration methods of topicarbamide in children: a preliminary clinical study

Xu Xu1, Lianxin Zhang1, Jingjing Jiang1, Chengyue Zhang1,()   

  1. 1. Department of Ophthalmology, Beijing Children’s Hospital, Beijing 100045, China
  • Received:2023-10-18 Online:2024-01-15 Published:2024-04-30
  • Contact: Chengyue Zhang

Abstract:

Objective

To investigate the pupil-dilating effects of different administration methods of compound topicarbamide eye drops in children.

Methods

This is a prospective randomized controlled study in which 88 patients (168 eyes) who received fundus examination under general anesthesia at the Department of Ophthalmology of Beijing Children's Hospital from May 2022 to December 2022 were included. These patients were divided randomly into either an experimental group or a control group. Compound topiramide was used for three times every three minutes before surgery in the control group. Compound topiramide was administered for four times every five minutes in the experimental group. The pupil diameters were measured before application of eye drop as well as 0 minute and 20 minutes after application.

Results

There was no significant differences in age or gender between the control group and the experimental group (P>0.05). The pupil diameters before application and 0 minute and 20 minutes after application in the control group were (3.88±0.52) mm, (4.81±0.77) mm, and (6.12±0.90) mm, respectively; the corresponding values in the experimental group were (3.78±0.38) mm, (6.14±1.00) mm, and (7.58±1.01) mm. There was a statistically significant difference in pupil diameter between the two groups at 0 min and 20 min after usage (P<0.05).

Conclusion

The new administration method of compound topicarbamide (four times once every five minutes) can achieve better effect on pupil size for children who need fundus examination.

Key words: Children, Pupil, Fundus examination

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