Abstract:

This paper reports the case of a middle-aged female patient who used a variety of topical medications alone or in combination because of repeated rashes for more than 6 months, which resulted in progressive aggravation of skin lesions, extensive skin ulceration with infection, invasive wound surface, and systemic inflammatory reaction. The lesions involved 30% of total body surface area. The main diagnosis at admission was severe large area skin ulcer with systemic inflammatory response syndrome. After admission, multi-disciplinary consultation was performed, related immunologic and inflammatory indicators were detected, autoimmune and immunodeficiency diseases were excluded, and systemic comprehensive treatment, personalized sequential treatment of wounds, and precise psychological intervention in stages were applied. After being hospitalized for more than one month, the patient recovered and was discharged. This paper discusses the causes of the disease, systemic and local treatment, and physical and psychological therapy, highlighting the evaluation of immune system function, management of OTC drug sales, and medication use education.

Key words: Skin ulcer, Skin infection, Medication misuse