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Chinese Journal of Clinicians(Electronic Edition) ›› 2024, Vol. 18 ›› Issue (07): 633-640. doi: 10.3877/cma.j.issn.1674-0785.2024.07.004

• Clinical Research • Previous Articles    

Association between serum vitamin levels and differentiated thyroid cancer

Fei Yang1, Tengfei Liu2, Zhijun Zhao1, Ruicong Li1, Jie Zhang1, Yan Liu1, Zhen Zhao1,()   

  1. 1.Department of Otolaryngology-Head and Neck Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
    2.Department of Head and Neck Thyroid Surgery, Xingtai People's Hospital, Xingtai 054000, China
  • Received:2024-07-01 Online:2024-07-15 Published:2024-11-18
  • Contact: Zhen Zhao

Abstract:

Objective

To investigate the association between serum vitamin levels and differentiated thyroid cancer (DTC).

Methods

We retrospectively analyzed 50 patients with differentiated thyroid cancer admitted to the Fourth Hospital of Hebei Medical University from January 2021 to December 2022. Fifty patients with nodular goiter who underwent thyroidectomy were included as controls. The levels of vitamins A, E, and D in serum, as well as the concentration of methylmalonic acid (MMA), were by high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Results

The serum concentrations of vitamin A and E in patients with DTC were significantly lower than those of controls(P<0.05). Patients with BRAF-positive DTC had significantly serum vitamin D concentrations than those with BRAF-negative DTC (P<0.05). As the clinical stage of DTC patients increased, vitamin D concentrations decreased significantly (P<0.05), indicating an increase in disease severity.

Conclusion

Serum vitamin levels are associated with the occurrence and disease progression of DTC, especially vitamin D. This finding provides new ideas for future prevention and treatment of DTC, including monitoring and possible supplementation of vitamins to improve patients’ quality of life and prognosis.

Key words: Serum vitamin levels, Differentiated thyroid cancer, Clinical stage, T stage, Correlation

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