Advances in research of intratumoral microbiome in breast cancer

doi:10.3877/cma.j.issn.1674-0785.2024.09.007

Abstract

Abstract:

The intratumoral microbiome refers to the microbial community residing within tumors，forming a crucial part of the tumor microenvironment. With advancements in metagenomic technologies，there has been a deeper understanding of the composition and functions of these microbial communities.Growing evidence suggests that microorganisms， such as bacteria， can indeed survive within various tumor tissues， including breast cancer， and are associated with tumorigenesis， disease progression， and drug resistance. This review summarizes the intratumoral microbiota related to the initiation， progression， and recurrence of breast cancer， elucidating their mechanisms of action. Additionally， this paper also explores the potential clinical applications of targeting the tumor micro-ecosystem for precision treatment of breast cancer.

Key words: Breast cancer, Intratumoral microbiome, Pathogenesis, Research progress

Qi Liu, Shoukai Wang, Shuai Wang, Yuqing Su, Zhuang Ma, Haijun Chen, Pilei Si. Advances in research of intratumoral microbiome in breast cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(09): 841-845.

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