Septic cardiomyopathy is a form of reversible myocardial injury caused by sepsis, contributing significantly to the mortality associated with sepsis. The pathophysiological mechanisms underlying septic cardiomyopathy are intricate, involving a multitude of factors such as cytokine release, myocardial cell injury or death, mitochondrial dysfunction, disrupted calcium homeostasis, and abnormal nitric oxide synthesis. As a complex clinical syndrome, the management of septic cardiomyopathy requires a thorough understanding of these pathophysiological processes and the application of multifaceted therapeutic strategies. With ongoing research advancements and the accumulation of clinical insights, enhancements in the diagnosis and treatment of septic cardiomyopathy are expected, potentially leading to a decrease in sepsis-related mortality. This article aims to review the current research developments regarding the pathophysiological mechanisms, clinical presentations, diagnostic approaches, and therapeutic interventions for septic cardiomyopathy.