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中华临床医师杂志(电子版) ›› 2018, Vol. 12 ›› Issue (09) : 530 -534. doi: 10.3877/cma.j.issn.1674-0785.2018.09.010

所属专题: 文献

综述

环形RNA与相关疾病研究进展
张沛1, 高春林1, 夏正坤1,()   
  1. 1. 210002 南京军区南京总医院儿科
  • 收稿日期:2018-04-02 出版日期:2018-05-01
  • 通信作者: 夏正坤
  • 基金资助:
    江苏省重点研发计划-临床前沿技术项目(BE2017719); 江苏省儿科医学创新团队项目(CXTDA2017022); 南京军区南京总医院基金项目(2016038)

Advances in understanding relationship between circular RNAs and diseases

Pei Zhang1, Chunlin Gao1, Zhengkun Xia1,()   

  1. 1. Department of Pediatrics, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China
  • Received:2018-04-02 Published:2018-05-01
  • Corresponding author: Zhengkun Xia
  • About author:
    Corresponding author: Xia Zhengkun, Email:
引用本文:

张沛, 高春林, 夏正坤. 环形RNA与相关疾病研究进展[J]. 中华临床医师杂志(电子版), 2018, 12(09): 530-534.

Pei Zhang, Chunlin Gao, Zhengkun Xia. Advances in understanding relationship between circular RNAs and diseases[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(09): 530-534.

环形RNA(circular RNA,circ RNA)是由前体RNA的5′末端和3′末端共价闭合形成一类非编码RNA,可竞争内源性RNA,具有miRNA海绵作用,调控基因的转录过程。circRNA与疾病的发生、发展和治疗关系密切,有望成为潜在的新型分子标志物和分子靶向治疗的靶点。

Circular RNAs are noncoding RNAs formed by 5' and 3' back-splicing of precursor RNAs, which are complementary to endogenous RNAs and function as miRNA sponges and modifiers of genetic transcription. CircRNAs are closely related to the occurrence, development, and therapy of many diseases, which makes circRNAs be potential novel molecular markers and targets for molecular targeted therapy.

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