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中华临床医师杂志(电子版) ›› 2020, Vol. 14 ›› Issue (09) : 730 -734. doi: 10.3877/cma.j.issn.1674-0785.2020.09.013

所属专题: 文献

综述

肿瘤干细胞在结直肠癌耐药及转移过程中作用的研究进展
殷志豪1, 张芝良2, 肖嘉伍1, 樊奇2, 熊德海3,()   
  1. 1. 637000 四川南充,川北医学院;404000 重庆三峡中心医院肠道外科
    2. 404000 重庆三峡中心医院肠道外科;404000 重庆万州区胃肠疾病诊疗技术创新研究中心
    3. 404000 重庆三峡中心医院肠道外科
  • 收稿日期:2020-03-09 出版日期:2020-09-15
  • 通信作者: 熊德海

Progress in understanding the role of tumor stem cells in drug resistance and metastasis in colorectal cancer

Zhihao Yin1, Zhiliang Zhang2, Jiawu Xiao1, Qi Fan2, Dehai Xiong3,()   

  1. 1. North Sichuan Medical College, Nanchong 637000, China; Department of Intestinal Surgery, Three Gorges Center Hospital, Chongqing 404000, China
    2. Department of Intestinal Surgery, Three Gorges Center Hospital, Chongqing 404000, China; Wanzhou District Gastrointestinal Disease Diagnosis and Treatment Technology Innovation Research Center, Chongqing 404000, China
    3. Department of Intestinal Surgery, Three Gorges Center Hospital, Chongqing 404000, China
  • Received:2020-03-09 Published:2020-09-15
  • Corresponding author: Dehai Xiong
  • About author:
    Corresponding author: Xiong Dehai, Email:
引用本文:

殷志豪, 张芝良, 肖嘉伍, 樊奇, 熊德海. 肿瘤干细胞在结直肠癌耐药及转移过程中作用的研究进展[J]. 中华临床医师杂志(电子版), 2020, 14(09): 730-734.

Zhihao Yin, Zhiliang Zhang, Jiawu Xiao, Qi Fan, Dehai Xiong. Progress in understanding the role of tumor stem cells in drug resistance and metastasis in colorectal cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(09): 730-734.

结直肠癌是全世界癌症相关死亡的主要原因之一,绝大多数结直肠癌患者死于外科手术后的复发和转移。越来越多的证据揭示了肿瘤干细胞(CSC)的存在及其在增强治疗抵抗和转移中的作用。CSC是肿瘤细胞中的一小部分,它能引发肿瘤的形成并使肿瘤产生异质性。此外,CSC对各种细胞毒因子有抵抗力并因此使结直肠癌术后患者产生耐药及转移。本文就近年来有关结直肠癌干细胞在肿瘤的耐药性及肿瘤转移方面的研究进展进行综述,以期为结直肠癌的治疗策略的选择提供参考。

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. The vast majority of colorectal cancer patients die of recurrence and metastasis after surgery. More and more evidence has revealed the existence of cancer stem cells (CSC) and its role in cancer resistance and metastasis. Tumor stem cells are a small fraction of tumor cells that can trigger tumor formation and make the tumor heterogeneous. In addition, tumor stem cells are resistant to a variety of cytotoxic factors and thus result in drug resistance and metastasis in patients with colorectal cancer after surgery.

1
Kreso A, Dick JE. Evolution of the cancer stem cell model [J]. Cell Stem Cell, 2014, 14(3): 275-291.

URL    
2
Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea—a paradigm shift [J]. Cancer Research, 2006, 66(4): 1883-1890.
3
Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J]. Nature medicine, 1997, 3(7): 730-737.
4
Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells [J]. Nature, 2007, 445(7123): 111-115.
5
Chae YC, Kim JH. Cancer stem cell metabolism: target for cancer therapy [J]. BMB Reports, 2018, 51(7): 319-326.
6
Liskova A, Kubatka P, Samec M, et al. Dietary phytochemicals targeting cancer stem cells [J]. Molecules, 2019, 24(5): 899.
7
Wu C, Alman BA. Side population cells in human cancers [J]. Cancer Lett, 2008, 268(1): 1-9.
8
Tang DG, Patrawala L, Calhoun T, et al. Prostate cancer stem/progenitor cells: identification, characterization, and implications [J]. Mol Carcinog, 2007, 46(1): 1-14.
9
Kang MK, Kang SK. Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma [J]. Stem Cells Dev, 2007, 16(5): 837-847.
10
Dalerba P, Clarke MF. Cancer stem cells and tumor metastasis: first steps into uncharted territory [J]. Cell Stem Cell, 2007, 1(3): 241-242.
11
Najafi M, Farhood B, Mortezaee K, et al. Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance [J]. J Cancer Res Clin Oncol, 2020, 146(1): 19-31.
12
Pouyafar A, Heydarabad MZ, Abdolalizadeh J, et al. Modulation of lipolysis and glycolysis pathways in cancer stem cells changed multipotentiality and differentiation capacity toward endothelial lineage [J]. Cell & Bioscience, 2019, 9(1): 30.
13
Hermann PC, Trabulo SM, Jr BS, et al. multimodal treatment eliminates cancer stem cells and leads to long-term survival in primary human pancreatic cancer tissue xenografts [J]. PloS One, 2013, 8.
14
Jagust P, de Luxán-Delgado B, Parejo-Alonso B, et al. Metabolism-based therapeutic strategies targeting cancer stem cells [J]. Front Pharmacol, 2019, 10: 203.
15
Prost S, Relouzat F, Spentchian M, et al. Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists [J]. Nature, 2015, 525(7569): 380-383.
16
Arceci RJ. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J]. Yearbook of Oncology, 2008, 2008: 286-287.
17
Tsunekuni K, Konno M, Haraguchi N, et al. CD44/CD133-positive colorectal cancer stem cells are sensitive to trifluridine exposure [J]. Sci Rep, 2019, 9(1): 1-8.
18
Barzegar Behrooz A, Syahir A, Ahmad S. CD133: beyond a cancer stem cell biomarker [J]. J Drug Target, 2019, 27(3): 257-269.
19
Li J, Chen JN, Zeng TT, et al. CD133+ liver cancer stem cells resist interferon-gamma-induced autophagy [J]. BMC Cancer, 2016, 16(1): 15.
20
Wu C, Alman BA. Side population cells in human cancers [J]. Cancer Lett, 2008, 268(1): 1-9.
21
Ho MM, Ng AV, Lam S, et al. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells [J]. Cancer Research, 2007, 67(10): 4827-4833.
22
Haraguchi N, Utsunomiya T, Inoue H, et al. Characterization of a side population of cancer cells from human gastrointestinal system [J]. Stem Cells, 2006, 24(3): 506-513.
23
Xiong B, Ma LI, Hu X, et al. Characterization of side population cells isolated from the colon cancer cell line SW480 [J]. Int J Oncol, 2014, 45(3): 1175-1183.

URL    
24
Guo Q, Grimmig T, Gonzalez G, et al. ATP-binding cassette member B5 (ABCB5) promotes tumor cell invasiveness in human colorectal cancer [J]. J Biol Chem, 2018, 293(28): 11166-11178.
25
Link W. Cancer Drug Resistance [A]. In: Principles of Cancer Treatment and Anticancer Drug Development: Springer, 2019: 77-85.
26
Liu P, Liao J, Tang Z, et al. Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway [J]. Cell Death & Differentiation, 2014, 21(1): 124-135.

URL    
27
Yu M, Ocana A, Tannock IF. Reversal of ATP-binding cassette drug transporter activity to modulate chemoresistance: why has it failed to provide clinical benefit? [J]. Cancer Metastasis Rev, 2013, 32(1-2): 211-227.

URL    
28
Akram M. Mini-review on glycolysis and cancer [J]. J Cancer Educ, 2013, 28(3): 454-457.

URL    
29
Ishimoto T, Nagano O, Yae T, et al. CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth [J]. Cancer Cell, 2011, 19(3): 387-400.

URL    
30
Schieber MS, Chandel NS. ROS links glucose metabolism to breast cancer stem cell and EMT phenotype [J]. Cancer Cell, 2013, 23(3): 265-267.

URL    
31
Carr AC, Cook J. Intravenous vitamin C for cancer therapy-identifying the current gaps in our knowledge [J]. Front Physiol, 2018, 9: 1182.
32
Lee WJ. The prospects of vitamin C in cancer therapy [J]. Immune Network, 2009, 9(5): 147.
33
Vincent Z, Urakami K, Maruyama K, et al. CD133-positive cancer stem cells from Colo205 human colon adenocarcinoma cell line show resistance to chemotherapy and display a specific metabolomic profile [J]. Genes Cancer, 2014, 5(7-8): 250.
34
Eyler CE, Rich JN. Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis [J]. J Clin Oncol, 2008, 26(17): 2839.
35
Skvortsova I, Debbage P, Kumar V, et al. Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling [J]. Semi Cancer Biol, 2015, 35: 39-44.
36
Cammareri P, Scopelliti A, Todaro M, et al. Aurora-a is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells [J]. Cancer Res, 2010, 70(11): 4655-4665.
37
Fulda S. Regulation of apoptosis pathways in cancer stem cells [J]. Cancer lett, 2013, 338(1): 168-173.

URL    
38
Makino S, Takahashi H, Okuzaki D, et al. DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer [J]. Carcinogenesis, 2020 Mar 10. pii: bgaa016.
39
Shafabakhsh R, Reiter RJ, Davoodabadi A, et al. Melatonin as a potential inhibitor of colorectal cancer: molecular mechanisms [J]. J Cell Biochem, 2019, 120(8): 12216-12223.
40
Li G, Liu C, Yuan J, et al. CD133+ single cell-derived progenies of colorectal cancer cell line SW480 with different invasive and metastatic potential [J]. Clin Exp Metastasis, 2010, 27(7): 517-527.

URL    
41
Hermann PC, Huber SL, Herrler T, et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer [J]. Cell Stem Cell, 2007, 1(3): 313-323.

URL    
42
Khatami F, Tavangar SM, Pour NK. Genomics, proteomics, and metabolomics of cancer stem cells (CSCs) [A]. In: Genomics, Proteomics, and Metabolomics: Springer, 2019: 159-179.
43
Brabletz T, Jung A, Spaderna S, et al. Migrating cancer stem cells—an integrated concept of malignant tumour progression [J]. Nat Rev Cancer, 2005, 5(9): 744-749.
44
Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease [J]. Cell, 2009, 139(5): 871-890.
45
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, et al. Autoregulation of E-cadherin expression by cadherin-cadherin interactions [J]. J Cell Biol, 2003, 163(4): 847-857.
46
Pal I, Rajesh Y, Banik P, et al. Prevention of epithelial to mesenchymal transition in colorectal carcinoma by regulation of the E-cadherin-β-catenin-vinculin axis [J]. Cancer lett, 2019, 452: 254-263.
47
De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression [J]. Nat Rev Cancer, 2013, 13(2): 97-110.
48
Terasaki M, Ikuta M, Kojima H, et al. Dietary fucoxanthin induces anoikis in colorectal adenocarcinoma by suppressing integrin signaling in a murine colorectal cancer model [J]. J Clin Med, 2020, 9(1): 90.
49
An H, Kim JY, Oh E, et al. Salinomycin promotes anoikis and decreases the CD44+/CD24-stem-like population via inhibition of STAT3 activation in MDA-MB-231 cells [J]. PLoS One, 2015, 10(11): e0141919.
50
Kruyt FA, Schuringa JJ. Apoptosis and cancer stem cells: implications for apoptosis targeted therapy [J]. Biochem Pharmacol, 2010, 80(4): 423-430.

URL    
51
Kim SY, Hong SH, Basse PH, et al. Cancer stem cells protect non-stem cells from anoikis: bystander effects [J]. J Cell biochem, 2016, 117(10): 2289-2301.
52
Makena MR, Ranjan A, Thirumala V, et al. Cancer stem cells: Road to therapeutic resistance and strategies to overcome resistance [J]. Biochim Biophys Acta Mol Basis Dis, 2020, 1866(4): 165339.
53
Kozovska Z, Gabrisova V, Kucerova L. Colon cancer: cancer stem cells markers, drug resistance and treatment [J]. Biomed Pharmacother, 2014, 68(8): 911-916.

URL    
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