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中华临床医师杂志(电子版) ›› 2020, Vol. 14 ›› Issue (09) : 730 -734. doi: 10.3877/cma.j.issn.1674-0785.2020.09.013

所属专题: 文献

综述

肿瘤干细胞在结直肠癌耐药及转移过程中作用的研究进展
殷志豪1, 张芝良2, 肖嘉伍1, 樊奇2, 熊德海3,()   
  1. 1. 637000 四川南充,川北医学院;404000 重庆三峡中心医院肠道外科
    2. 404000 重庆三峡中心医院肠道外科;404000 重庆万州区胃肠疾病诊疗技术创新研究中心
    3. 404000 重庆三峡中心医院肠道外科
  • 收稿日期:2020-03-09 出版日期:2020-09-15
  • 通信作者: 熊德海

Progress in understanding the role of tumor stem cells in drug resistance and metastasis in colorectal cancer

Zhihao Yin1, Zhiliang Zhang2, Jiawu Xiao1, Qi Fan2, Dehai Xiong3,()   

  1. 1. North Sichuan Medical College, Nanchong 637000, China; Department of Intestinal Surgery, Three Gorges Center Hospital, Chongqing 404000, China
    2. Department of Intestinal Surgery, Three Gorges Center Hospital, Chongqing 404000, China; Wanzhou District Gastrointestinal Disease Diagnosis and Treatment Technology Innovation Research Center, Chongqing 404000, China
    3. Department of Intestinal Surgery, Three Gorges Center Hospital, Chongqing 404000, China
  • Received:2020-03-09 Published:2020-09-15
  • Corresponding author: Dehai Xiong
  • About author:
    Corresponding author: Xiong Dehai, Email:
引用本文:

殷志豪, 张芝良, 肖嘉伍, 樊奇, 熊德海. 肿瘤干细胞在结直肠癌耐药及转移过程中作用的研究进展[J/OL]. 中华临床医师杂志(电子版), 2020, 14(09): 730-734.

Zhihao Yin, Zhiliang Zhang, Jiawu Xiao, Qi Fan, Dehai Xiong. Progress in understanding the role of tumor stem cells in drug resistance and metastasis in colorectal cancer[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(09): 730-734.

结直肠癌是全世界癌症相关死亡的主要原因之一,绝大多数结直肠癌患者死于外科手术后的复发和转移。越来越多的证据揭示了肿瘤干细胞(CSC)的存在及其在增强治疗抵抗和转移中的作用。CSC是肿瘤细胞中的一小部分,它能引发肿瘤的形成并使肿瘤产生异质性。此外,CSC对各种细胞毒因子有抵抗力并因此使结直肠癌术后患者产生耐药及转移。本文就近年来有关结直肠癌干细胞在肿瘤的耐药性及肿瘤转移方面的研究进展进行综述,以期为结直肠癌的治疗策略的选择提供参考。

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. The vast majority of colorectal cancer patients die of recurrence and metastasis after surgery. More and more evidence has revealed the existence of cancer stem cells (CSC) and its role in cancer resistance and metastasis. Tumor stem cells are a small fraction of tumor cells that can trigger tumor formation and make the tumor heterogeneous. In addition, tumor stem cells are resistant to a variety of cytotoxic factors and thus result in drug resistance and metastasis in patients with colorectal cancer after surgery.

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