Association of serum 25 (OH) D levels with semen parameters and sex hormones in infertility men

doi:10.3877/cma.j.issn.1674-0785.2017.11.002

Abstract

Abstract:

Objective

To investigate the correlation between serum 25(OH)D level and semen parameters and sex hormones in infertile males.

Methods

145 infertile men were collected from the Assisted Reproductive Centre of the First Hospital of Shanxi Medical University, and their serum levels of 25(OH)D, semen analysis parameters, serum levels of hormone were retrospectively analyzed. Patients were divided into three groups according to the level of 25(OH)D with 36 cases in deficiency group (25(OH)D<25 mmol/L), 66 cases in insufficiency group (25 mmol/L ≤25(OH) D<50 mmol/L) and 43 cases in normal group (50 mmol/L≤25(OH)D).

Results

There were significant differences in BMI, sperm concentration, sperm motility, progesterone(P) level, and testosterone(T) levels among the 3 groups (F=3.725, P=0.026; F=15.974, P<0.001; F=7.367, P=0.001; F=22.872, P<0.001 and F=5.187, P=0.007, respectively). Significant variables were adjusted in ordinal logistic regression model using serum 25(OH)D as dependent variable. We observed a positive correlation between serum 25(OH)D level and sperm motility, sperm density, P level (OR=1.304, P<0.001, OR=1.042, P<0.001, OR=3.904, P<0.001).

Conclusions

The serum 25(OH)D levels were positively correlated with sperm motility, sperm concentration and P level in infertile males, which indicated that 25(OH)D might affect semen quality of this population.

Key words: Vitamin D, Male infertility, Sex hormone, Semen parameters

Mingming Wei, Yujie He, Xiaolian Liu, Xiao Jing. Association of serum 25 (OH) D levels with semen parameters and sex hormones in infertility men[J]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(11): 1873-1877.

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Figures/Tables 4

References 21

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组别	例数	年龄（岁）	BMI（kg/m²）
25（OH）D缺乏组	36	33.31±4.62	25.98±2.79^a
25（OH）D不足组	66	32.80±4.49	24.79±2.98^b
25（OH）D正常组	43	31.83±4.38	24.27±2.59^b
F值		1.127	3.725
P值		0.327	0.026

组别	例数	年龄（岁）	BMI（kg/m²）
25（OH）D缺乏组	36	33.31±4.62	25.98±2.79^a
25（OH）D不足组	66	32.80±4.49	24.79±2.98^b
25（OH）D正常组	43	31.83±4.38	24.27±2.59^b
F值		1.127	3.725
P值		0.327	0.026

组别	例数	pH	精子浓度（10⁶/ml）	精子活力（%）	正常形态精子百分率（%）
25（OH）D缺乏组	36	7.23±0.15	35.01±18.10^c	50.75±16.11^e	11.61±4.23
25（OH）D不足组	66	7.26±0.17	59.43±24.87^d	55.46±20.52^e	11.36±5.88
25（OH）D正常组	43	7.23±0.11	69.58±37.04^d	65.52±14.27^f	12.41±3.60
F值		0.428	15.974	7.367	0.604
P值		0.653	<0.001	0.001	0.548

组别	例数	pH	精子浓度（10⁶/ml）	精子活力（%）	正常形态精子百分率（%）
25（OH）D缺乏组	36	7.23±0.15	35.01±18.10^c	50.75±16.11^e	11.61±4.23
25（OH）D不足组	66	7.26±0.17	59.43±24.87^d	55.46±20.52^e	11.36±5.88
25（OH）D正常组	43	7.23±0.11	69.58±37.04^d	65.52±14.27^f	12.41±3.60
F值		0.428	15.974	7.367	0.604
P值		0.653	<0.001	0.001	0.548

组别	例数	E2（pmol/L）	P（nmol/L）	FSH（IU/L）	LH（IU/L）	T（nmol/L）	PRL（mIU/L）
25（OH）D缺乏组	36	116.15±35.86	1.49±0.64^g	4.51±1.76	4.61±3.05	14.72±2.58^j	206.84±52.85
25（OH）D不足组	66	125.70±38.44	2.18±0.78^h	4.79±2.53	3.90±1.83	14.37±4.32^j	226.16±103.89
25（OH）D正常组	43	130.10±33.21	2.66±0.83ⁱ	4.14±1.50	3.86±1.47	16.75±4.09^k	235.59±85.09
F值		1.497	22.872	1.26	1.576	5.187	1.074
P值		0.227	<0.001	0.287	0.21	0.007	0.345

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