Application of Treg cell detection in sepsis

doi:10.3877/cma.j.issn.1674-0785.2019.05.013

Abstract

Abstract:

Sepsis is a common disease in the intensive care unit, with a high mortality rate. At present, the treatment of sepsis is mainly based on symptomatic support treatment. However, the contradiction between inflammatory reaction period and immunosuppressive period in the course of sepsis has brought great controversy to clinical immunotherapy. Previous studies have confirmed that the change of T cell subset ratio is correlated with the course and prognosis of sepsis. Treg cells, a type of T-cell classification, may become a new biomarker in the diagnosis and treatment of sepsis because of their strong inhibitory effect on body cells and humoral immunity. This paper reviews the application of Treg cell detection in sepsis, with an aim to provide reference for clinical diagnosis and treatment of sepsis.

Key words: Sepsis, T cells, Treg cells, Immunohistochemistry, Flow cytometry

Kali Hu, Wei Li. Application of Treg cell detection in sepsis[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(05): 385-388.

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References 19

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CD4^＋T细胞		特异表面标志物	分化条件	产生细胞因子	功能
Th		?	?	?	?
?	Th1	CXCR3^＋CCR4^-	Th1，IL-12、IL-18等	INF-γ、IL-2等	针对胞内的病原体
?	Th2	CCR4^＋CXCR34^-	IL-4	IL-4、IL-5等	针对胞外寄生虫
?	Th17	CCR6^＋CD161^＋	IL-1β、IL-6等	IL-17、IL-21、IL-22、IL-26等	针对胞外细菌及真菌感染
Tfh		CXCR5^＋	IL-6、IL-21、IL-27等	-	辅助B细胞增殖和产生抗体
Tr		?	?	?	?
?	Treg	CD25^＋D127^-	-	FOXP3	免疫抑制作用
?	Tr1	CD25^-D127^-	-	IL-10等	免疫抑制作用

CD4^＋T细胞		特异表面标志物	分化条件	产生细胞因子	功能
Th		?	?	?	?
?	Th1	CXCR3^＋CCR4^-	Th1，IL-12、IL-18等	INF-γ、IL-2等	针对胞内的病原体
?	Th2	CCR4^＋CXCR34^-	IL-4	IL-4、IL-5等	针对胞外寄生虫
?	Th17	CCR6^＋CD161^＋	IL-1β、IL-6等	IL-17、IL-21、IL-22、IL-26等	针对胞外细菌及真菌感染
Tfh		CXCR5^＋	IL-6、IL-21、IL-27等	-	辅助B细胞增殖和产生抗体
Tr		?	?	?	?
?	Treg	CD25^＋D127^-	-	FOXP3	免疫抑制作用
?	Tr1	CD25^-D127^-	-	IL-10等	免疫抑制作用

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