Multi-center study of blood lipids in younger patients with hypertensive cerebral hemorrhage

doi:10.3877/cma.j.issn.1674-0785.2019.08.003

Abstract

Abstract:

Objective

To explore the characteristics of blood lipids in younger patients with hypertensive intracerebral hemorrhage (HICH).

Methods

We collected the blood samples from HICH patients in eight hospitals, and then divided them into either a younger patient group (30-40 years old) or an older patient group (50-60 years old). At the same time, younger and older healthy people were randomly selected as control groups. The levels of total cholesterol (TCH), triglyceride (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) in blood were examined, and their differences were compared between different groups by t-tests.

Results

The levels of TG and HDL-C presented a significant difference between the younger patient and healthy groups [(1.95±1.34) mmol/L vs (1.25±0.63) mmol/L, t=5.40, P<0.001; (1.18±0.45) mmol/L vs (1.34±0.36) mmol/L, t=3.23, P=0.001], and TG level in the younger patient group was significantly higher than that of the older patient group [(1.95±1.34) mmol/L vs (1.43±1.09) mmol/L, t=3.39; P=0.001]. However, the level of HDL-C in the younger patients was significantly lower than that in the older HICH patients [(1.18±0.45) mmol/L vs (1.35±0.38) mmol/L, t=3.30; P=0.001]. Besides, 46.5% of younger HICH patients had abnormal TG levels.

Conclusion

Abnormal level of TG or HDL-C is an important risk factor for HICH in younger patients, and monitoring and management of blood lipids such as TG is a promising preventive method against HICH in younger people.

Key words: Younger age, Hypertensive intracerebral hemorrhage, Blood lipids, Triglyceride

Yuan Chai, Weiping Liu, Panpan Xian, Qiang Luo, Yu Miao, Hujin Zhang, Cairui Fan, Jianzhong Gao, Chenguang Jia, Yang Liu, Menglong Song, Yuqi Zhang, Qianfa Long. Multi-center study of blood lipids in younger patients with hypertensive cerebral hemorrhage[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(08): 572-576.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2019.08.003

https://zhlcyszz.cma-cmc.com.cn/EN/Y2019/V13/I08/572

Figures/Tables 2

References 11

1	徐辉，赵薇，方岩, 等. 青年脑出血的病因及危险因素分析[J]. 中国实用神经疾病杂志, 2015, 19(4): 10-11.
2	任大为. 62例青年脑卒中患者临床病因及危险因素分析[J]. 中国卫生标准管理, 2016, 7(9): 13-15.
3	王应鹏，王归真，殷彩桥, 等. 不同年龄与性别之间高血压病患者血脂特点[J]. 第四军医大学学报, 2006, 27(19): 1782-1785.
4	Koivunen RJ, Satopaa J, Meretoja A, et al. Incidence, risk factors, etiology, severity and short-term outcome of non-traumatic intracerebral hemorrhage in young adults[J]. Eur J Neurol, 2015, 22(1): 123-132.
5	Ding J, Sigurdsson S, Garcia M, et al. Risk Factors Associated With Incident Cerebral Microbleeds According to Location in Older People: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study[J]. JAMA Neurol, 2015, 72(6): 682-688.
6	Misra UK, Kalita J, Somarajan BI. Recurrent intracerebral hemorrhage in patients with hypertension is associated with APOE gene polymorphism: a preliminary study[J]. J Stroke Cerebrovasc Dis, 2013, 22(6): 758-763.
7	王忠诚. 王忠诚神经外科学[M]. 第2版. 武汉：湖北科学技术出版社, 2015: 124-138.
8	张福征，王才永，张磊, 等. 神经内镜与开颅手术治疗高血压脑出血的疗效比较[J]. 中华神经外科杂志, 2015, 31(1): 19-21.
9	Kalita J, Goyal G, Kumar P, et al. Intracerebral hemorrhage in young patients from a tertiary neurology center in North India[J]. J Neurol Sci, 2014, 336(1-2): 42-47.
10	Gu B, Zhao YC, Yang ZW, et al. HindIII polymorphism in the lipoprotein lipase gene and hypertensive intracerebral hemorrhage in the Chinese Han population[J]. J Stroke Cerebrovasc Dis, 2014, 23(6): 1275-1281.
11	闫丽，曹烨，汪秋实, 等. 高血压患者脑卒中发病影响因素Cox回归分析[J]. 中国公共卫生, 2016, 32(6): 748-752.

组别	例数	TCH（mmol/L）		TG（mmol/L）		HDL-C（mmol/L）		LDL-C（mmol/L）
组别	例数	>5.17	<2.23	>1.69	<0.56	>1.68	<0.90	>4.00	<1.30
低龄HICH组	114	33（28.9）	0	53（46.5）^a	3（2.6）	7（6.1）^b	24（21.1）	10（8.8）	2（1.8）
低龄体检群组	139	27（19.4）	1（0.7）	25（18.0）	13（9.4）	19（13.7）	9（6.5）	6（4.3）	6（4.3）
中老年HICH组	136	49（36.0）	0	31（22.8）	7（5.1）	21（15.4）	10（7.4）	16（11.8）	3（2.2）
中老年体检群组	140	51（36.4）	0	42（30.0）	6（4.3）	15（10.7）	9（6.4）	21（15.0）	2（1.4）

组别	例数	TCH（mmol/L）		TG（mmol/L）		HDL-C（mmol/L）		LDL-C（mmol/L）
组别	例数	>5.17	<2.23	>1.69	<0.56	>1.68	<0.90	>4.00	<1.30
低龄HICH组	114	33（28.9）	0	53（46.5）^a	3（2.6）	7（6.1）^b	24（21.1）	10（8.8）	2（1.8）
低龄体检群组	139	27（19.4）	1（0.7）	25（18.0）	13（9.4）	19（13.7）	9（6.5）	6（4.3）	6（4.3）
中老年HICH组	136	49（36.0）	0	31（22.8）	7（5.1）	21（15.4）	10（7.4）	16（11.8）	3（2.2）
中老年体检群组	140	51（36.4）	0	42（30.0）	6（4.3）	15（10.7）	9（6.4）	21（15.0）	2（1.4）

组别	例数	TCH	TG	HDL-C	LDL-C
低龄HICH组	114	4.65±1.07	1.95±1.34	1.18±0.45	2.75±0.90
低龄体检人群组	139	4.33±0.88	1.25±0.63	1.34±0.36	2.54±0.82
中老年HICH组	136	4.85±1.17	1.43±1.09	1.35±0.38	2.98±1.02
中老年体检人群组	140	4.62±0.97	1.48±0.76	1.30±0.32	2.76±0.83
t值	?	2.57	5.40	3.23	1.89
^aP值	?	0.011	<0.001	0.001	0.06
t值	?	3.88	2.64	0.55	3.46
^bP值	?	<0.001	0.009	0.581	0.001
t值	?	1.40	3.39	3.30	1.89
^cP值	?	0.159	0.001	0.001	0.06

组别	例数	TCH	TG	HDL-C	LDL-C
低龄HICH组	114	4.65±1.07	1.95±1.34	1.18±0.45	2.75±0.90
低龄体检人群组	139	4.33±0.88	1.25±0.63	1.34±0.36	2.54±0.82
中老年HICH组	136	4.85±1.17	1.43±1.09	1.35±0.38	2.98±1.02
中老年体检人群组	140	4.62±0.97	1.48±0.76	1.30±0.32	2.76±0.83
t值	?	2.57	5.40	3.23	1.89
^aP值	?	0.011	<0.001	0.001	0.06
t值	?	3.88	2.64	0.55	3.46
^bP值	?	<0.001	0.009	0.581	0.001
t值	?	1.40	3.39	3.30	1.89
^cP值	?	0.159	0.001	0.001	0.06

[1]	Xueying Cai, Jiayi Chen, Longhuan Zeng, Jianrong Wang, Ying Zhu, Wei Hu. Clinical characteristics of patients with hypertriglyceridemia acute pancreatitis during pregnancy: a 10-year single-center retrospective analysis [J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2021, 14(05): 393-399.
[2]	Shi Wang, Jin Wang, Tingting Li, Dan Wang, Lingkong Zeng. Congenital diarrhea and enteropathies caused by DGAT1 gene mutation: a case report and literature review [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(02): 192-197.
[3]	Yinglin Ye, Xiaomeng Guo, Yanwei Zheng, Rongzhen Jiang. Analysis of body fat percentage and its influencing factors of neonates delivered by obese pregnant women [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2021, 17(05): 536-544.
[4]	Lingxia Zhao, Lingkong Zeng, Baohuan Cai, Wenhao Yuan. Diagnosis and treatment of child with congenital generalized lipodystrophy caused by BSCL2 gene mutation and literature review [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2021, 17(05): 574-581.
[5]	lei Xu, Jie Sun, Xianzhi Chen. Application of hemopurification for hyperlipidemic severe pancreatitis [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(04): 464-468.
[6]	Haicheng She, Shenshen Yan, Pengfei Sun, Yimeng Jiang, Fangfang Fan, Jia Jia, Yan Zhang. The relationship between triglyceride glucose index and retinal arteriosclerosis grading in a community-based population [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2021, 11(05): 262-267.
[7]	Shaonian Xu, Yongming Zhang, Zhenshan Huang, Jun Ding, Guowei Jiang, Feng Qian, Lianfu Zhang. Clinical effect analysis of robot-assisted stereotactic minimally invasive aspiration and drainage in the treatment of hypertensive intracerebral hemorrhage [J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2022, 08(02): 76-80.
[8]	Zhengwei Liu, Lizhi Yi, Xilong Yin, Wenlong Kong, Zhisong Jiu, Wenyuan Zhang. Efficacy analysis of external drainage of conocephalic hematoma and neuroendoscopic surgery for senile hypertensive intracerebral hemorrhage in basal ganglia [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(05): 299-303.
[9]	Mo Yun, Maofang Li, Hao Wang, Dongyuan Liu. Clinical study of minimally invasive puncture and drainage combined with piracetam and urapidil in the treatment of hypertensive intracerebral hemorrhage in basal ganglia [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(05): 278-285.
[10]	Lizhong Wang, Junsheng Chu, Lihui Zhao, Huiyuan Sun, Qing Hou, Qi Ding, Junfei Yan, Yuan Hou, Wu Yuan, Wei Wang. Comparison of clinical efficacy of neuroendoscopy and microscopic surgery on early hypertensive intracerebral hemorrhage in basal ganglia [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2022, 12(02): 69-73.
[11]	Ying Lin, Jianhong Li, Hongquan Lu, Junling Chen. Relationship between serum n-pentamerin 3 level and blood lipids, cognitive function, and prognosis in patients with acute cerebral infarction [J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(05): 420-424.
[12]	Meiyu Zhang, Shengli Wu, Weiting Xiang, Kehong Sun, Nong Li. The diagnostic value of the triglyceride-glucose index in predicting the risk of non-alcoholic fatty liver disease in physical examination population [J]. Chinese Journal of Diagnostics(Electronic Edition), 2022, 10(03): 152-157.
[13]	Feifei Lai, Shu Li, Weiqiong Wu, Yu Li, Huifang Li, Xiaona Zhang. Effects of electronic digital remote management on glucose and lipid metabolism and quality of life in patients with type 2 diabetes [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(02): 104-108.
[14]	Lihua Jiang, Ling Guan, Jiali Huang, Xinliang Han. Effect of atorvastatin calcium combined with ticagrelor on patients with coronary heart disease and hyperlipidemia and the effect of serum cytokines [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2021, 07(03): 165-169.
[15]	Xiyu Zhao, Ling Ling, Chao Zhang, Shan Lu, Lei Xiang, Wei Yue. Characteristics of risk factors for hypertensive intracerebral hemorrhage in different bleeding sites and ages [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(03): 165-171.

Please choose a citation manager

Content to export