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Chinese Journal of Clinicians(Electronic Edition) ›› 2019, Vol. 13 ›› Issue (08): 572-576. doi: 10.3877/cma.j.issn.1674-0785.2019.08.003

Special Issue:

• Clinical Researches • Previous Articles     Next Articles

Multi-center study of blood lipids in younger patients with hypertensive cerebral hemorrhage

Yuan Chai1, Weiping Liu2, Panpan Xian1, Qiang Luo1, Yu Miao1, Hujin Zhang1, Cairui Fan3, Jianzhong Gao4, Chenguang Jia5, Yang Liu6, Menglong Song7, Yuqi Zhang8, Qianfa Long1,()   

  1. 1. Department of Neurosurgery, Minimally Invasive and Translational Medicine Center, Xi′an Central Hospital, Xi′an 710003, China
    2. Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi′an 710032, China
    3. Department of Neurosurgery, the 187th Central Hospital of the People's Liberation Army, Haikou 571159, China
    4. Department of Neurosurgery, Yulin First Hospital, Yulin 718000, China
    5. Department of Neurosurgery, Zhuzhou People's Hospital, Zhuzhou 412008, China
    6. Department of Neurosurgery, the Third People's Hospital of Mianyang, Mianyang 621000, China
    7. Department of Emergency, Sichuan Provincial People's Hospital, Chengdu 610072, China
    8. Department of Neurosurgery, Binzhou People's Hospital, Binzhou 256610, China
  • Received:2018-05-17 Online:2019-04-15 Published:2019-04-15
  • Contact: Qianfa Long
  • About author:
    Corresponding author: Long Qianfa, Email:

Abstract:

Objective

To explore the characteristics of blood lipids in younger patients with hypertensive intracerebral hemorrhage (HICH).

Methods

We collected the blood samples from HICH patients in eight hospitals, and then divided them into either a younger patient group (30-40 years old) or an older patient group (50-60 years old). At the same time, younger and older healthy people were randomly selected as control groups. The levels of total cholesterol (TCH), triglyceride (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) in blood were examined, and their differences were compared between different groups by t-tests.

Results

The levels of TG and HDL-C presented a significant difference between the younger patient and healthy groups [(1.95±1.34) mmol/L vs (1.25±0.63) mmol/L, t=5.40, P<0.001; (1.18±0.45) mmol/L vs (1.34±0.36) mmol/L, t=3.23, P=0.001], and TG level in the younger patient group was significantly higher than that of the older patient group [(1.95±1.34) mmol/L vs (1.43±1.09) mmol/L, t=3.39; P=0.001]. However, the level of HDL-C in the younger patients was significantly lower than that in the older HICH patients [(1.18±0.45) mmol/L vs (1.35±0.38) mmol/L, t=3.30; P=0.001]. Besides, 46.5% of younger HICH patients had abnormal TG levels.

Conclusion

Abnormal level of TG or HDL-C is an important risk factor for HICH in younger patients, and monitoring and management of blood lipids such as TG is a promising preventive method against HICH in younger people.

Key words: Younger age, Hypertensive intracerebral hemorrhage, Blood lipids, Triglyceride

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