Characteristics of early-onset colorectal cancer and comparisons between China and the West

doi:10.3877/cma.j.issn.1674-0785.2021.02.011

Abstract

Abstract:

The incidence of colorectal cancer in young people is on the rise all over the world. Compared to ordinary colorectal cancer, the epidemiologic features, clinical characteristics, pathological pattern, and genetic mutations of colorectal cancer in young people are different. In addition, there are also significant differences in some features of colorectal cancer in young Chinese and Western populations. This review is aimed at the above aspects, in order to answer the relevant debate over the characteristics of colorectal cancer in young populations.

Key words: Young adult, Colorectal cancer, Epidemiology, Clinicopathological, Risk factors

Ke An, Yanzhao Wang, Zilong Wang, Fuming. Lei. Characteristics of early-onset colorectal cancer and comparisons between China and the West[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(02): 139-143.

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https://zhlcyszz.cma-cmc.com.cn/EN/Y2021/V15/I02/139

References 50

1	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2018, 68(6): 394-424.
2	Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017 [J]. CA Cancer J Clin, 2017, 67(3): 177-193.
3	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015 [J]. CA Cancer J Clin, 2016, 66(2): 115-132.
4	Pan R, Zhu M, Yu C, et al. Cancer incidence and mortality: a cohort study in China, 2008-2013 [J]. Int J Cancer, 2017, 141(7): 1315-1323.
5	Li HL, Gao YT, Zheng Y, et al. Incidence trends of colorectal cancer inurban Shanghai,1973-2005 [J].Zhonghua Yu Fang Yi Xue ZaZhi, 2009, 43(10): 875-879.
6	Chen W, Zheng R, Baade PD, et al. Cancer statisticsin China, 2015 [J]. CA Cancer J Clin, 2016, 66(2): 115-132.
7	Patel SG, Ahnen DJ. Colorectal cancer in the young [J]. Gastroenterol, 2018, 20: 15 .
8	McKay A, Donaleshen J, Helewa RM, et al. Does young age influence the prognosis of colorectal cancer: a population-based analysis [J]. World J Surg Oncol, 2014, 12: 370.
9	Inra JA, Syngal S. Colorectal cancer in young adults [J]. Dig Dis Sci, 2015, 60(3): 722-733.
10	Stoffel EM, Murphy CC. Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults [J]. Gastroenterology, 2020, 158(2): 341-353.
11	莫善竞, 王吉民. 大肠癌的流行病、病因学 [J]. 中华肿瘤杂志, 1979, 1(1): 75
12	李清晨, 代文杰, 许军. 青年期结直肠癌的临床特点及误诊分析 [J]. 消化外科, 2006, 5(5): 377-379.
13	Bao P, Zheng Y, Wu CX, et al. Cancer incidence in urban Shanghai, 1973-2010: an updated trend and age-period-cohort effects [J]. BMC Cancer, 2016, 16(1): 284.
14	Liu PH, Wu K, Ng K, et al. Association of obesity with risk of early-onset colorectal cancer among women [J]. JAMA Oncol, 2019, 5(1): 37-44.
15	Rosato V, Bosetti C, Levi F, et al. Risk factors for young-onset colorectal cancer [J]. Cancer Causes Control, 2013, 24(2): 335-341.
16	Kim JY, Jung YS, Park JH, et al. Different risk factors for advanced colorectal neoplasm in young adults [J]. World J Gastroenterol, 2016, 22(13): 3611-3620.
17	Zheng X, Nguyen LH, Liu PH, et al. 983-Comprehensive assessment of diet quality and risk of early-onset colorectal adenoma [J]. Gastroenterology, 2019, 156: S-208.
18	Dominguez-Bello MG, Costello EK, Contreras M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns [J]. Proc Natl Acad Sci U S A, 2010, 107(26): 11971-11975.
19	Stoffel EM, Koeppe E, Everett J, et al. Germline genetic features of young individuals with colorectal cancer [J]. Gastroenterology, 2018, 154(4): 897-905.
20	Feinberg AP. The key role of epigenetics in human disease prevention and mitigation [J]. N Engl J Med, 2018, 378(14): 1323-1334.
21	Chang DT, Pai RK, Rybicki LA, et al. Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features [J]. Mod Pathol, 2012, 25(8): 1128-1139.
22	Mork ME, You YN, Ying J, et al. High prevalence of hereditary cancer syndromes in adolescents and young adults with colorectal cancer [J]. J Clin Oncol, 2015, 33(31): 3544-3549.
23	Wimmer K, Etzler J. Constitutional mismatch repair-defificiency syndrome: have we so far seen only the tip of an iceberg? [J]. Hum Genet, 2008, 124(2):105-122.
24	Tanskanen T, Gylfe AE, Katainen R. Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients [J]. Scand J Gastroenterol, 2013, 48(6): 672-678.
25	Valle L, Hernández-Illán E, Bellido F. New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis [J]. Hum Mol Genet, 2014, 23(13): 3506-3512.
26	Weren RD, Ligtenberg MJ, Geurts A. NTHL1 and MUTYH polyposis syndromes: two sides of the same coin? [J]. J Pathol, 2018, 244(2): 135-142.
27	Bellido F, Sowada N, Mur P, et al. Association between germline mutations in BRF1, a subunit of the RNA polymerase III transcription complex, and hereditary colorectal cancer [J]. Gastroenterology, 2018, 154(1): 181-194. e20.
28	Mur P, De Voer RM, Olivera-Salguero R, et al. Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis [J]. Mol Cancer, 2018, 17(1): 23.
29	Khan SA, Morris M, Idrees K, et al. Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients [J]. J Pediatr Surg, 2016, 51(11): 1812-1817.
30	Watson R, Liu TC, Ruzinova MB. High frequency of KRAS mutation in early onset colorectal adenocarcinoma: implications for pathogenesis [J]. Hum Pathol, 2016, 56: 163-170.
31	Rho YS, Gilabert M, Polom K, et al. Comparing clinical characteristics and outcomes of young-onset and lateonset colorectal cancer: an international collaborative study [J]. Clin Colorectal Cancer, 2017, 16(4): 334-342.
32	Perea J, Arriba M, Rodriguez Y, et al. Frequency and impact of KRAS mutation in early onset colorectal cancer [J]. Hum Pathol, 2017, 61: 221-222.
33	Agesen TH, Berg M, Clancy T, et al. CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer [J]. Genes Immun, 2011, 12(8): 653-662.
34	Siegel RL, Miller KD, Goding Sauer A, et al. Colorectal cancer statistics, 2020 [J]. CA Cancer J Clin, 2020, 70(3): 145-164.
35	Low EE, Demb J, Liu L, et al. Risk factors for early-onset colorectal cancer [J]. Gastroenterology, 2020, 159(2): 492-501. e7.
36	李乐乐, 林沛楠, 孙婧, 等. 青年结直肠癌患者临床及病理特征分析 [J/OL]. 中华结直肠疾病电子杂志, 2017, 6(4): 310-315.
37	Fu JF, Huang YQ, Yang J, et al. Clinical characteristics and prognosis of young patients with colorectal cancer in Eastern China [J]. World J Gastroenterol, 2013, 19(44): 8078-8084.
38	Murphy CC, Wallace K, Sandler RS. Racial disparities in incidence of young-onset colorectal cancer and patient survival [J]. Gastroenterology, 2019, 156(4): 958-965.
39	Inra JA, Syngal S. Colorectal cancer in young adults [J]. Dig Dis Sci, 2015, 60(3): 722-733.
40	Fu J, Yang J, Tan Y, Jiang M. Young patients (≤ 35 years old) with colorectal cancer have worse outcomes due to more advanced disease: a 30-year retrospective review [J]. Medicine (Baltimore), 2014, 93(23): e135.
41	Riaz R, Masood N, Benish A. Red flag symptoms: detailed account of clinicopathological features in young-onset colorectal cancer [J]. Intest Res, 2017, 15(2): 203-207.
42	Bleyer A, Barr R, Hayes-Lattin B, et al. The distinctive biology of cancer in adolescents and young adults [J]. Nat Rev Cancer, 2008, 8(4): 288-298.
43	Shida D, Ahiko Y, Tanabe T, et al. Shorter survival in adolescent and young adult patients, compared to adult patients, with stage IV colorectal cancer in Japan [J]. BMC Cancer, 2018, 18(1): 334.
44	Kolarich A, George TJ, Hughes SJ, et al. Rectal cancer patients younger than 50 years lack a survival benefifit from NCCN guideline-directed treatment for stage II and III disease [J]. Cancer, 2018, 124: 3510-3519.
45	Rodriguez L, Brennan K, Karim S, et al. Disease characteristics, clinical management, and outcomes of young patients with colon cancer: a population-based study [J]. Clin Colorectal Cancer, 2018, 17(4): e651-e661.
46	Li M, Li JY, Zhao AL, et al. Do young patients with colorectal cancer have a poorer prognosis than old patients? [J]. J Surg Res, 2011, 167(2): 231-236.
47	Liang PS, Allison J, Ladabaum U, et al. Potential intended and unintended consequences of recommending initiation of colorectal cancer screening at age 45 years [J]. Gastroenterology, 2018, 155(4): 950-954.
48	Ladabaum U, Mannalithara A, Meester RGS. Cost-effectiveness and national effects of initiating colorectal cancer screening for average-risk persons at age 45 years instead of 50 years [J]. Gastroenterology, 2019, 157(1): 137-148.
49	Marcus PM, Pashayan N, Church TR, et al. Population-based precision cancer screening: a symposium on evidence, epidemiology, and next steps [J]. Cancer Epidemiol Biomarkers Prev, 2016, 25(11): 1449-1455.
50	Jeon J, Du M, Schoen RE, et al. Determining risk of colorectal cancer and starting age of screening based on lifestyle, environmental, and genetic factors [J]. Gastroenterology, 2018, 154(8): 2152-2164. e19.

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