Clinical significance of expression of DDX5 in thyroid cancer

doi:10.3877/cma.j.issn.1674-0785.2023.04.004

Abstract

Abstract:

Objective

To investigate the expression of DEAD-box RNA helicase 5 (DDX5) in thyroid cancer and to analyze its clinical significance.

Methods

Specimens of thyroid cancer (n=100) and benign thyroid lesions (n=100) surgically removed at the hospitals belonging to Linfen Medical Association from October 2014 to September 2021 were selected, and the clinicopathological data of these patients were collected. Western blot and immunohistochemistry were used to detect the expression of DDX5 in thyroid cancer and benign lesions, and the results were statistically analyzed.

Results

The expression of DDX5 protein in thyroid carcinoma was significantly higher than that in benign tissues (30.44±3.71 vs 13.22±2.83, P＜0.01). The positive expression of DDX5 was significantly correlated with lymph node metastasis and TNM stage of thyroid cancer (P＜0.05), but not with age, gender, or pathological type (P＞0.05).

Conclusion

Overexpression of DDX5 might be involved in the occurrence and development of thyroid cancer.

Key words: Thyroid cancer, Benign thyroid lesions, DDX5

Xueqin Zhao, Xuefeng Su, Dongwei Ren, Bingbing Cui, Zhendong Wang, Hui Li. Clinical significance of expression of DDX5 in thyroid cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(04): 386-390.

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Figures/Tables 4

References 24

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组别	例数	DDX5［例（%）］		P值
组别	例数	阳性	阴性	P值
甲状腺癌组织	100	64（64.0）	36（36.0）	P＜0.05
良性病变组织	100	31（31.0）	69（69.0）	P＜0.05
性别				P=0.892
女性	84	54（64.6）	30（35.7）
男性	16	10（62.5）	6（37.5）
年龄（岁）				P=0.797
＜55	74	42（56.8）	32（43.2）
≥55	26	14（53.8）	12（46.2）
病理类型				P=0.617
甲状腺乳头状癌	49	27（55.1）	22（44.9）
甲状腺滤泡状癌	25	13（52.0）	12（48.0）
甲状腺髓样癌	18	7（38.9）	11（64.1）
间变性甲状腺癌症	8	5（62.5）	3（37.5）
TNM分级				P＜0.05
Ⅰ~Ⅱ	55	28（51.0）	27（49.0）
Ⅲ~Ⅳ	45	35（77.8）	10（22.2）
淋巴转移				P＜0.05
是	69	55（79.7）	14（20.3）
否	31	10（32.3）	21（67.7）

组别	例数	DDX5［例（%）］		P值
组别	例数	阳性	阴性	P值
甲状腺癌组织	100	64（64.0）	36（36.0）	P＜0.05
良性病变组织	100	31（31.0）	69（69.0）	P＜0.05
性别				P=0.892
女性	84	54（64.6）	30（35.7）
男性	16	10（62.5）	6（37.5）
年龄（岁）				P=0.797
＜55	74	42（56.8）	32（43.2）
≥55	26	14（53.8）	12（46.2）
病理类型				P=0.617
甲状腺乳头状癌	49	27（55.1）	22（44.9）
甲状腺滤泡状癌	25	13（52.0）	12（48.0）
甲状腺髓样癌	18	7（38.9）	11（64.1）
间变性甲状腺癌症	8	5（62.5）	3（37.5）
TNM分级				P＜0.05
Ⅰ~Ⅱ	55	28（51.0）	27（49.0）
Ⅲ~Ⅳ	45	35（77.8）	10（22.2）
淋巴转移				P＜0.05
是	69	55（79.7）	14（20.3）
否	31	10（32.3）	21（67.7）

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