Relationship between gut microbiota and Alzheimer′s disease

doi:10.3877/cma.j.issn.1674-0785.2018.02.010

Abstract

Abstract:

Alzheimer′s disease (AD), the most common form of dementia, is a degenerative disease of the central nervous system characterized by progressive memory loss and mental and behavioral dysfunction. The pathogenesis of AD remains unclear. A large number of microorganisms reside in the human gastrointestinal ecosystem, and the gut microbiota interacts with the host through the microbiota-gut-brain axis, which is a bidirectional communication system. Disorders in the gut microbiota are closely associated with the pathogenesis of obesity, type 2 diabetes mellitus, and AD. The purpose of this review is to summarize and discuss the current findings regarding the role of the gut microbiota in the development of AD. Understanding the relationship between gut microbiota and AD may provide new insights into the development of novel therapeutic strategies for AD.

Key words: Alzheimer′s disease, Gut microbiota, Inflammation, Obesity, Type 2 diabetes mellitus

Yanyan Wang, Jianying Li, Bai Han. Relationship between gut microbiota and Alzheimer′s disease[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(02): 107-110.

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