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Chinese Journal of Clinicians(Electronic Edition) ›› 2019, Vol. 13 ›› Issue (05): 389-392. doi: 10.3877/cma.j.issn.1674-0785.2019.05.014

Special Issue:

• Review • Previous Articles     Next Articles

Role of interleukin-33 in bronchial asthma

Xin Li1, Yuanyuan Liu2, Caiqing Zhang1,()   

  1. 1. Department of Respiratory Medicine, Qianfoshan Hospital, Jinan 250014, China
    2. Department of Respiratory Medicine, Affiliated Hospital of Taishan Medical College, Taian 271000, China
  • Received:2019-01-28 Online:2019-03-01 Published:2019-03-01
  • Contact: Caiqing Zhang
  • About author:
    Corresponding author: Zhang Caiqing, Email:

Abstract:

Interleukin (IL)-33, belonging to the IL-1 cytokine family, induces a Th2 immune response through the ST2 membrane receptor and plays an important role in the regulation of the immune system. IL-33 is mainly secreted by epithelial cells and can also be produced by other cells such as bone marrow cells, dendritic cells, macrophages, and mast cells. The IL-33 receptor ST2 is widely expressed in a variety of cells. Th2 cells, mast cells, basophils, and eosinophils areall involved in the development of bronchial asthma (BA). IL-33 is thought to be the initiating factor of the Th2 type of immune response, and the development of allergic diseases such as asthma is induced by activating the innate immunity and adaptive immunity. Further understanding of the biological characteristics of IL-33 can help to elucidate its role in the treatment of asthma.

Key words: Bronchial asthma, IL-33, ST2

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