Significance of expression of human N-acetyltransferase 10 protein in clear cell renal cell carcinoma

doi:10.3877/cma.j.issn.1674-0785.2020.03.015

Abstract

Abstract:

Objective

To detect the expression of human N-acetyltransferase 10 (NAT10) in clear cell renal cell carcinoma (CCRCC) and to analyze its clinical significance.

Methods

On hundred CCRCC samples were obtained for analysis. Each case underwent microscopic observation and immunohistochemical staining for NAT10.

Results

Immunohistochemical staining for NAT10 was positive in all cases. NAT10 was distributed in the nucleus and cytoplasm of tumor cells, predominantly in the nucleoli.

Conclusion

NAT10 could be detected in CCRCC, and it could be used as a potential marker for the nucleoli and the diagnosis of CCRCC.

Key words: Clear cell renal cell carcinoma, Acetyltransferases, Immunohistochemistry

Qi Shen, Shuai Hu, Jun Li, Jinghua Wang, Libo Liu, Qun He. Significance of expression of human N-acetyltransferase 10 protein in clear cell renal cell carcinoma[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(03): 228-231.

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Figures/Tables 2

References 13

1	凌云，龚一雷，李挺，等. N-乙酰转移酶NAT10在软组织肿瘤中的表达及意义 [J]. 现代生物医学进展, 2006, 6(6): 1-6.
2	关立照，沈棋，孙颖，等. 人乙酰转移酶样蛋白的核仁定位及在肿瘤中的表达 [J].北京大学学报(医学版), 2008, 40(4): 347-351.
3	Shen Q, Zheng X, McNutt MA, et al. NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules [J]. Exp Cell Res, 2009, 315(10): 1653-1667.
4	Moch H, Humphrey PA, Ulbright TM, et al. WHO Classification of Tumors of the Urinary System and Male Genital Organs [M]. Lyon: IARC Prss, 2016.
5	Dagher J, Delahunt B, Rioux-Leclercq N, et al, Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading [J]. Histopathology, 2017, 71(6): 918-925.
6	ScheerU, Hock R. Structure and function of the nucleolus [J]. Curr Opin Cell Biol, 1999, 11(9): 385- 390.
7	Weber JD, KuoML, Bothner B, et al. Cooperative signals governing ARF2 mdm2 interaction and nucleolar localizati on of the complex [J]. Mol Cell Biol, 2000, 20(7): 2517-2528.
8	Derenzini D, TrerèA, Pession M, et al. Nucleolar size indicates the rapidity of cell proliferation in cancer tissues [J]. Pathol, 2000, 191(2): 181-186.
9	Orsolic I, Jurada D, Pullen N, et al. The relationship between the nucleolus and cancer: Current evidence and emerging paradigms [J]. Semin Cancer Biol, 2016, 37-38: 36-50.
10	Lv J, Liu H, Wang Q, et al. Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT [J]. Biochem Biophys Res Commun, 2003, 311: 506-513.
11	Liu H, Ling Y, Gong Y, et al. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation [J]. Mol Cell Biochem, 2007, 300(1-2): 249-258
12	Chi YH, Haller K, Peloponese JM Jr, et al. Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes [J]. J Biol Chem, 2007, 282(37): 27447-27458.
13	迟英凯，沈棋，王教辰，等. 间叶肉瘤端粒长度变化与相关调节蛋白表达的关系[J]. 北京大学学报(医学版), 2008, 40(4): 363-368.

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