Treatment of hematologic malignancies with same monosomal karyotype: Report of two cases and review of the literature

doi:10.3877/cma.j.issn.1674-0785.2020.07.020

Abstract

Abstract:

Objective

To assess the therapeutic effects of different regimens in two hematologic malignancy patients with del (5) and perform a review of the literature.

Methods

The changes of blood para, clinical manifestations, and cytogenetics were investigated in two patients with hematologic malignancies who were treated with lenalidomide and decitabine-based regimens, respectively.

Results

Although the two patients received different treatments, they both achieved cytogenetic remission.

Conclusion

The same monosomal karyotype may predict different prognoses in different diseases, and treatment based on guidelines should be adopted in order to achieve good results.

Key words: Karyotyping, Prognosis, Lenalidomide, Decitabine

Guanchen Bai, Yuyu Liu, Miaomiao Gao, Sifeng Gao, Jilei Zhang, Qingliang Teng. Treatment of hematologic malignancies with same monosomal karyotype: Report of two cases and review of the literature[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(07): 569-572.

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