Diagnostic value of sputum microRNA-21 in lung cancer: A Meta-analysis

doi:10.3877/cma.j.issn.1674-0785.2021.03.004

Abstract

Abstract:

Objective

To evaluate the diagnostic value of sputum miRNA-21 in lung cancer and provide evidence for the clinical diagnosis and treatment of this malignancy.

Methods

The PubMed, Cochrane Library, Embase, CNKI, SinoMed, VIP, and Wanfangdata databases were searched for relevant articles, which were then selected according to the inclusion and exclusion criteria. Stata and MetaDiSc were used for Meta-analysis.

Results

Four articles including five studies of diagnostic value of sputum miRNA-21 in lung cancer were used for this Meta-analysis. The results showed that the pooled sensitivity was 0.72 (95%CI: 0.66-0.78), the pooled specificity was 0.77 (95%CI: 0.71-0.82), the pooled diagnostic odds ratio was 8.71 (95%CI: 5.46-13.89), and the area under the summary receiver operating characteristic curve was 0.8263.

Conclusion

MiRNA-21 in sputum is of high value in the diagnosis of lung cancer. Limited by the number and quality of the included studies, there still needs more clinical trials to verify our findings.

Key words: MicroRNA-21, Lung cancer, Sputum, Diagnosis, Meta-analysis

Han Li, Rong Gao, Bingdi Yan, Changying Hu, Mengmeng Hou, Junling Yang. Diagnostic value of sputum microRNA-21 in lung cancer: A Meta-analysis[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(03): 177-181.

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Figures/Tables 6

References 19

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作者	年限	国家	TP（例）	FP（例）	FN（例）	TN（例）	病例/对照（例）	地理人种	肺癌分型	对照类型	内参	QUADAS（分）
Su J 等^［5］	2015	美国	42	14	14	59	56/73	非洲，欧洲	NSCLC	无癌吸烟者	U6	12
Xing L 等^［6］	2015	美国	47	17	13	45	60/62	欧洲	-	肺良性疾病	U6，miR 16	8
杨小倩等^［7］	2013	中国	20	6	4	18	24/24	亚洲	NSCLC	肺良性疾病	U6	8
Yu L 等^［8］	2010	美国	26	7	10	29	36/36	非洲，欧洲	NSCLC	健康体检者	U6	8
Yu L 等^［8］	2010	美国	38	15	26	43	64/58	非洲，欧洲	NSCLC	健康体检者	U6	8

作者	年限	国家	TP（例）	FP（例）	FN（例）	TN（例）	病例/对照（例）	地理人种	肺癌分型	对照类型	内参	QUADAS（分）
Su J 等^［5］	2015	美国	42	14	14	59	56/73	非洲，欧洲	NSCLC	无癌吸烟者	U6	12
Xing L 等^［6］	2015	美国	47	17	13	45	60/62	欧洲	-	肺良性疾病	U6，miR 16	8
杨小倩等^［7］	2013	中国	20	6	4	18	24/24	亚洲	NSCLC	肺良性疾病	U6	8
Yu L 等^［8］	2010	美国	26	7	10	29	36/36	非洲，欧洲	NSCLC	健康体检者	U6	8
Yu L 等^［8］	2010	美国	38	15	26	43	64/58	非洲，欧洲	NSCLC	健康体检者	U6	8

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