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Chinese Journal of Clinicians(Electronic Edition) ›› 2021, Vol. 15 ›› Issue (07): 509-514. doi: 10.3877/cma.j.issn.1674-0785.2021.07.006

• Clinical Research • Previous Articles     Next Articles

Clinical significance of changes of serum TFF3 and VASH-1 levels in diabetic nephropathy patients

Xinmei Huang1, Jingyan Lu1, Hongmei Gao1, Yarong Si1, Shoupin Xie2, Huaqin Chen3,()   

  1. 1. Department of Nephrology, Lanzhou First People's Hospital, Lanzhou 730050, China
    2. Department of Neurology, Lanzhou First People's Hospital, Lanzhou 730050, China
    3. Department of Hyperbaric Oxygen, Lanzhou First People's Hospital, Lanzhou 730050, China
  • Received:2021-04-09 Online:2021-07-15 Published:2021-11-09
  • Contact: Huaqin Chen

Abstract:

Objective

To investigate the relationship among serum TFF3 and VASH-1 levels and diabetic nephropathy.

Methods

A total of 203 patients with type 2 diabetes admitted to Lanzhou First People's Hospital from January 2018 to June 2020 were selected, including 73 patients complicated with diabetic nephropathy (nephropathy group) and 130 patients without diabetic nephropathy (simple diabetes group). The nephropathy group was further divided into CKD stage 1/2 group (25 cases), CKD stage 3/4 group (32 cases), and CKD stage 5 group (16 cases) according to the staging criteria for CKD. Another 65 healthy volunteers were selected as a control group. Serum TFF3 and VASH-1 levels were detected, and clinical data were collected to analyze the relationship among TFF3, VASH-1, renal function indexes, and the incidence of diabetic nephropathy.

Results

Serum level of TFF3 in the nephropathy group was significantly higher than those of the simple diabetic group and control group (P<0.05), and VASH-1 level was significantly lower than those of the simple diabetic group and control group (P<0.05). TFF3 increased with the increase of CKD stage (P<0.05), while VASH-1 decreased with the increase of CKD stage (P<0.05). In the nephropathy group, TFF3 was positively correlated with BUN, Scr, and 24-h urine protein (r=0.769, 0.753, and 0.772, respectively, P<0.05), but negatively correlated with eGFR (r=-0.862, P<0.05). VASH-1 was negatively correlated with BUN, Scr, and 24-h urine protein (r=-0.786, -0.765, and -0.753, respectively, P<0.05), but positively correlated with eGFR (r=0.819, P<0.05). Multivariate Logistic regression analysis showed that hypertension (OR=1.680, 95%CI: 1.318-2.043, P=0.005), high insulin resistance index (OR=1.652, 95%CI: 1.313-1.991, P=0.003), high TFF3 (OR=1.619, 95%CI: 1.312-1.927, P=0.002) were risk factors for diabetic nephropathy, while high VASH-1 (OR=0.604, 95%CI: 0.405-0.898, P=0.001) was a protective factor.

Conclusion

The levels of serum TFF3 increase and those of serum VASH-1 decrease in diabetic nephropathy patients. High level of TFF3 and low level of VASH-1 may be associated with the incidence of diabetic nephropathy and the degree of renal function injury.

Key words: Diabetic nephropathy, Trefoil factor 3, Vasohibin 1

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