Clinical efficacy of Jeksung combined with anti-radiation spray for acute radiation stomatitis in patients with locally advanced head and neck tumors

doi:10.3877/cma.j.issn.1674-0785.2022.05.008

Abstract

Abstract:

Objective

To investigate the clinical efficacy of Jeksung combined with anti-radiation spray for radiotherapy-induced oral mucositis in patients with radiotherapy-induced oral mucositis.

Methods

From August 2020 to August 2021, 102 patients with radiotherapy-induced oral mucositis caused by locally advanced head and neck tumors admitted to The Affiliated Cancer Hospital of Guangzhou Medical University were selected. According to the random number table method, they were divided into either an observation group (n=51) or a control group (n=51). The observation group included 32 males and 19 females, with an average age of (56.32±7.86) years. The control group included 34 males and 17 females, with an average age of (55.87±8.39) years. Both groups were treated with intensity modulated radiotherapy (6996 cGy/33 f, 5 times a week) for locally advanced head and neck tumors. The control group was treated with anti-radiation spray, and the observation group was treated with Jeksung combined with anti-radiation spray. The efficacy of the two groups was evaluated 7 days after the end of radiotherapy. The short-term clinical efficacy was compared between the two groups. Radiotherapy-induced oral mucositis grade, numerical rating scale (NRS) score, oral assessment guide (OAG) score, and salivary interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were compared between the two groups before and after treatment.

Results

The total effective rate of the observation group was 84.31%, which was significantly higher than that of the control group (66.67%; P＜0.05). After treatment, the severity of radiotherapy-induced oral mucositis in both groups was lower than that before treatment (P＜0.05). The severity of radiotherapy-induced oral mucositis in the observation group was lower than that in the control group (P＜0.05). NRS score, OAG score, and salivary IL-6 and TNF-α in the two groups were decreased after treatment when compared with those before treatment (P＜0.05). NRS score, OAG score, and salivary IL-6 and TNF-α in the observation group were lower than those in the control group after treatment [2.85±0.45 vs 3.76±0.63, P＜0.001; 9.20±1.05 vs 12.76±1.96, P＜0.001; (13.85±2.97) ng/L vs (21.08±4.43) ng/L, P＜0.001; and (28.49±5.24) ng/L vs (39.96±6.56) ng/L, P＜0.001, respectively].

Conclusion

The short-term curative effect of Jeksung combined with anti-radiation spray for patients with locally advanced head and neck tumors with radiotherapy-induced oral mucositis is better than that of anti-radiation spray alone, which can relieve pain and improve oral condition.

Key words: Stomatitis, Locally advanced head and neck tumors, Radiotherapy-induced oral mucositis, Jeksung, Anti-radiation spray

Yu Zeng, Yanhao Kuang, Pan Gong, Quanbin Zhang, Bin Qi. Clinical efficacy of Jeksung combined with anti-radiation spray for acute radiation stomatitis in patients with locally advanced head and neck tumors[J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(05): 415-419.

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References 19

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组别	例数（男/女）	年龄（岁）	鼻咽癌/口咽癌/舌癌/牙龈癌（例）	体质指数（kg/m²）
观察组	51（32/19）	56.32±7.86	39/5/4/3	23.07±2.18
对照组	51（34/17）	55.87±8.39	40/4/5/2	22.78±2.09
χ²/t值	0.172	0.280	0.435	0.686
P值	0.679	0.780	0.933	0.494

组别	例数（男/女）	年龄（岁）	鼻咽癌/口咽癌/舌癌/牙龈癌（例）	体质指数（kg/m²）
观察组	51（32/19）	56.32±7.86	39/5/4/3	23.07±2.18
对照组	51（34/17）	55.87±8.39	40/4/5/2	22.78±2.09
χ²/t值	0.172	0.280	0.435	0.686
P值	0.679	0.780	0.933	0.494

时间		0级	Ⅰ级	Ⅱ级	Ⅲ级	Ⅳ级
治疗前	观察组	0	7（13.73）	30（58.82）	10（19.61）	4（7.84）
	对照组	0	9（17.65）	29（56.86）	12（23.53）	1（1.96）
治疗后	观察组	9（17.65）^a	25（49.02）^a	10（19.61）^a	6（10.76）^a	1（1.96）^a
	对照组	4（7.84）^a	20（39.22）^a	15（29.41）^a	11（21.57）^a	1（1.96）^a

时间		0级	Ⅰ级	Ⅱ级	Ⅲ级	Ⅳ级
治疗前	观察组	0	7（13.73）	30（58.82）	10（19.61）	4（7.84）
	对照组	0	9（17.65）	29（56.86）	12（23.53）	1（1.96）
治疗后	观察组	9（17.65）^a	25（49.02）^a	10（19.61）^a	6（10.76）^a	1（1.96）^a
	对照组	4（7.84）^a	20（39.22）^a	15（29.41）^a	11（21.57）^a	1（1.96）^a

时间		IL-6（ng/L）	TNF-α（ng/L）
治疗前	观察组	27.95±5.47	52.98±7.28
	对照组	28.36±6.32	54.23±5.12
t值		0.350	1.003
P值		0.727	0.318
治疗后	观察组	13.85±2.97^a	28.49±5.24^a
	对照组	21.08±4.43^a	39.96±6.56^a
t值		9.681	9.756
P值		＜0.001	＜0.001

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