Correlation of human papillomavirus subtype and load with severity and extent of cervical intraepithelial neoplasia

doi:10.3877/cma.j.issn.1674-0785.2020.05.011

Abstract

Abstract:

Objective

To investigate correlation of human papillomavirus (HPV) subtype and load with cervical lesion extent.

Methods

A retrospective analysis was performed on the clinical data of patients who underwent cervical cone resection and cervical loop electrosurgical excision procedure from January 2016 to December 2018 at the Department of Obstetrics and Gynecology of Peking University Shougang Hospital. According to the HPV subtype and postoperative pathological results, the extent of cervical lesions was compared. The correlation between HPV load and cervical lesion extent was also analyzed.

Results

Among patients infected with a single HPV subtype, the extent of high and low grade cervical lesions differed significantly between the patients infected by HPV16/18 and those infected by other subtypes (P<0.05). The extent of high and low grade cervical lesions did not differ significantly between the patients infected by multiple HPV subtypes and those infected by single HPV subtype (P>0.05). HPV load was positively correlated with the extent of high-grade cervical lesions (r=0.65, P<0.05), but negatively correlated with the extent of low-grade cervical lesions (r=-0.63, P<0.05).

Conclusion

HPV16/18 plays an important role in the development of cervical lesions. There is a correlation between HPV load and cervical lesion extent.

Key words: Human papillomavirus, Viral load, Cervix uteri lesion

Rui Kong, Qun Yao, Xiaobo Wu, Xiaohong Zhang, Ying Fan. Correlation of human papillomavirus subtype and load with severity and extent of cervical intraepithelial neoplasia[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(05): 376-379.

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References 20

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组别	例数	低级别鳞状上皮内病变	高级别鳞状上皮内病变
1组	43	3.11±1.76	4.58±1.24
2组	52	2.50±2.12^a	3.26±2.38^a
3组＋4组	8	2.80±1.76	2.52±1.45
F值	?	1.32	0.86
P值	?	<0.05	<0.05

组别	例数	低级别鳞状上皮内病变	高级别鳞状上皮内病变
1组	43	3.11±1.76	4.58±1.24
2组	52	2.50±2.12^a	3.26±2.38^a
3组＋4组	8	2.80±1.76	2.52±1.45
F值	?	1.32	0.86
P值	?	<0.05	<0.05

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