Association of selenium and selenoprotein with blood lipids in elderly people

doi:10.3877/cma.j.issn.1674-0785.2022.12.005

Abstract

Abstract:

Objective

To investigate the association between the levels of selenium and blood lipids in middle-aged and elderly people, and assess the mediatory effect of superoxide dismutase (SOD) in their association.

Methods

A cross-sectional study was conducted in 85 middle-aged and elderly people in Yichun. Blood samples were collected to determine the concentrations of selenium, selenoproteins [selenoprotein P (SEPP1) and glutathione peroxidase (GPX)], and blood lipids. Linear regression analyses were performed to investigate the association between the levels of selenium and SOD, as well as the association between the levels of selenium and blood lipids. Then,selenium biomarkers related to blood lipids were identified to further investigate whether there is any mediatory effect in the relationship between selenium biomakers and blood lipids.

Results

Linear regression analysis revealed that the level of selenium in plasma was not correlated with blood lipids, but the selenoproteins (SEPP1 and GPX) were negatively associated with low density protein cholesterol (LDL-C) and total cholesterol (TC). In addition, selenoproteins were found to be associated with SOD (P＜0.05). In the mediation analysis, SOD was found to be a significant mediator of the association between SEPP1 and LDL-C (P＜0.05).

Conclusion

Selenoproteins may reduce blood lipid levels by inhibiting oxidative stress.

Key words: Selenium, Selenoprotein P, Superoxide dismutase, Mediatory effect

Jiayang Zheng, Jinyu Lin, Zhangmin Wang, Qin Luo, Lin Zhang, LiQiang Qin, Jingsi Chen, Xuebin Yin. Association of selenium and selenoprotein with blood lipids in elderly people[J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(12): 1175-1179.

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Figures/Tables 5

References 25

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指标	类别	分布描述
年龄［median（IQR），year］	-	56（51，65）
性别（n，%）	男	38（44.7）
	女	47（55.3）
吸烟情况（n，%）	从不	61（71.8）
	现在/曾经吸烟	24（28.2）
饮酒情况（n，%）	从不	65（76.5）
	现在/曾经饮酒	20（23.5）
BMI［median（IQR），kg/m²］	-	21.8（20.1，24.2）
收缩压［median（IQR），mm Hg］	-	130（120，140）
舒张压［median（IQR），mm Hg］	-	80（75，90）
血浆硒［median（IQR），μg/L］	-	130.1（93.5，154.7）
SEPP1［median（IQR），μg/mL］	-	24.9（17.8，34.1）
GPX［median（IQR），U/L］	-	122.3（94.9，182.5）
SOD［median（IQR），U/mL］	-	48.7（28.2，93.6）
LDL-C［median（IQR），mmol/L］	-	2.0（2.6，3.6）
HDL-C［median（IQR），mmol/L］	-	1.1（0.8，1.4）
TC［median（IQR），mmol/L］	-	4.7（4.2，5.4）
TG［median（IQR），mmol/L］	-	1.1（0.8，1.9）

指标	类别	分布描述
年龄［median（IQR），year］	-	56（51，65）
性别（n，%）	男	38（44.7）
	女	47（55.3）
吸烟情况（n，%）	从不	61（71.8）
	现在/曾经吸烟	24（28.2）
饮酒情况（n，%）	从不	65（76.5）
	现在/曾经饮酒	20（23.5）
BMI［median（IQR），kg/m²］	-	21.8（20.1，24.2）
收缩压［median（IQR），mm Hg］	-	130（120，140）
舒张压［median（IQR），mm Hg］	-	80（75，90）
血浆硒［median（IQR），μg/L］	-	130.1（93.5，154.7）
SEPP1［median（IQR），μg/mL］	-	24.9（17.8，34.1）
GPX［median（IQR），U/L］	-	122.3（94.9，182.5）
SOD［median（IQR），U/mL］	-	48.7（28.2，93.6）
LDL-C［median（IQR），mmol/L］	-	2.0（2.6，3.6）
HDL-C［median（IQR），mmol/L］	-	1.1（0.8，1.4）
TC［median（IQR），mmol/L］	-	4.7（4.2，5.4）
TG［median（IQR），mmol/L］	-	1.1（0.8，1.9）

	LDL-C		HDL-C		TC		TG
	β	P值	β	P值	β	P值	β	P值
Model 1
血浆硒	0.088	0.425	-0.060	0.588	0.176	0.107	0.250	0.021
SEPP1	-0.212	0.046	0.063	0.564	-0.220	0.043	-0.107	0.332
GPX	-0.241	0.026	-0.081	0.463	-0.296	0.006	-0.056	0.611
Model 2
血浆硒	0.105	0.382	-0.001	0.991	0.198	0.096	0.203	0.086
SEPP1	-0.293	0.047	0.077	0.486	-0.213	0.051	-0.124	0.258
GPX	-0.242	0.027	-0.063	0.568	-0.301	0.005	-0.082	0.453
Model 3
血浆硒	0.101	0.406	0.001	0.997	0.194	0.108	0.200	0.089
SEPP1	-0.221	0.047	0.080	0.467	-0.227	0.039	-0.130	0.230
GPX	-0.247	0.025	-0.062	0.574	-0.306	0.005	-0.085	0.435

	LDL-C		HDL-C		TC		TG
	β	P值	β	P值	β	P值	β	P值
Model 1
血浆硒	0.088	0.425	-0.060	0.588	0.176	0.107	0.250	0.021
SEPP1	-0.212	0.046	0.063	0.564	-0.220	0.043	-0.107	0.332
GPX	-0.241	0.026	-0.081	0.463	-0.296	0.006	-0.056	0.611
Model 2
血浆硒	0.105	0.382	-0.001	0.991	0.198	0.096	0.203	0.086
SEPP1	-0.293	0.047	0.077	0.486	-0.213	0.051	-0.124	0.258
GPX	-0.242	0.027	-0.063	0.568	-0.301	0.005	-0.082	0.453
Model 3
血浆硒	0.101	0.406	0.001	0.997	0.194	0.108	0.200	0.089
SEPP1	-0.221	0.047	0.080	0.467	-0.227	0.039	-0.130	0.230
GPX	-0.247	0.025	-0.062	0.574	-0.306	0.005	-0.085	0.435

效应	β	SE	P值	Lower 95%CI	Upper 95%CI
A（暴露-中介变量）	3.325	0.252	＜0.001	2.825	3.826
B（中介变量-结局）	-0.005	0.002	0.031	-0.010	-0.001
C（直接效应）	0.006	0.009	0.511	-0.012	0.025
Ab（中介效应）	-0.017	0.007	0.015	-0.032	-0.004

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