To explore survey the status of anxiety and depression in residents of Nanning during the epidemic of Corona Virus Disease 2019 (COVID-19) to provide reference for psychological counseling of home residents in this special period.

From February 7 to February 14, 2020, a self-made general information questionnaire, the serf-rating anxiety scale (SAS), and the serf-rating depression scale (SDS) were administered via WeChat platform to investigate the anxiety and depression status of 312 residents in Nanning.

The mean SAS score in this study was (39.44±9.77), which was significantly higher than the Chinese norm (37.23±12.59, t=4.00, P<0.01). The mean SDS score was (45.22±11.74), which was also significantly higher than the Chinese norm (41.88±10.57, t=5.03, P<0.01). Multiple linear regression analysis showed that worrying about being infected and sleep disorder were risk factors for anxiety; low education level and sleep were risk factors for depression.

During the COVID-19 epidemic, residents of Nanning have negative feelings of anxiety and depression, especially those who are overly worried being about infected people, those with poor sleep quality, and those with a lower education level. We should pay more attention to the residents′ mental and psychological health.